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Differential Expression of CHL1 Gene during Development of Major Human Cancers
The role of CHL1 as a potentially novel specific biomarker in the early pathogenesis of two major histological types of renal cancer is supported and suggested that re-expression of the gene on the edge of tumor mass might promote local invasive growth and enable further metastatic spread in ovary, colon and breast cancer. Expand
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays
This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis and to design perspective sets of newly identified biomarkers to allow early detection, tumor progression, metastases and to discriminate between SCC and ADC with sensitivity and specificity of 80–100%. Expand
[Alteration of SEMA3B gene expression levels in epithelial tumors].
The results permitted to suggest a possible role of SEMA3B in inhibiting of growth of renal, ovarian and colorectal cancer cells. Expand
Novel miRNA genes methylated in lung tumors
- S. Rykov, D. Khodyrev, I. Pronina, T. Kazubskaya, V. Loginov, E. Braga
- Russian Journal of Genetics
The frequencies of mir-125b-1 and mir-137 methylation were shown for the first time to correlate with NSCLC progression (clinical stage and metastasis). Expand
Tumor Suppressor Function of the SEMA3B Gene in Human Lung and Renal Cancers
It is concluded that aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression. Expand
DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
Evidence is provided for the significant role of methylation in the deregulation of 12 miRNA genes in BC, identify putative novel functional miRNA-mRNA pairs, and suggest MIR-127 and Mir-125b-1 hypermethylation to be potential biomarkers of BC metastasis. Expand
Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis.
The impact of aberrant methylation on deregulation of 12 miRNAs in EOC, the involvement of 10 hypermethylated miRNA genes in metastasis (including peritoneal macro-metastases), and suggest novel potential biomarkers are shown. Expand
Novel miRNA genes hypermethylated in breast cancer
Three new genes with a high frequency of hypermethylation have been identified in breast cancer and the involvement of three miRNAs and the methylation of the genes that encode them in the pathogenesis of breast cancer to be suggested. Expand
[Methylation profile of group of miRNA genes in clear cell renal cell carcinoma; involvement in cancer progression].
The frequency of methylation of six miRNA genes was significantly higher in tumor samples than in samples of histologically normal tissue, suggesting the properties of tumor suppressors for the six mi RNA genes indicated in CCRCC. Expand
Methylation of promoter region of RAR-β2 gene in renal cell, breast, and ovarian carcinomas
- D. Khodyrev, V. Loginov, I. Pronina, T. Kazubskaya, R. Garkavtseva, E. Braga
- Biology, Medicine
- Russian Journal of Genetics
- 22 August 2008
A high methylation frequency in the gene promoter region of RAR-β2 gene is reported in RCC and a somewhat lower frequency in EOC, which is consistent with the published data. Expand