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Saponins as cytotoxic agents: a review
The correlations between the structure and the cytotoxicity of both steroid and triterpenoid saponins have been described as well as the most common mechanisms of action.
Allium ursinum: botanical, phytochemical and pharmacological overview
This mini-review summarizes the current knowledge on the phytochemistry and pharmacological properties of this valuable plant, with special emphasis on antimicrobial, cytotoxic, antioxidant, and cardio-protective effects.
Steroidal saponins from the genus Allium
- D. Sobolewska, K. Michalska, I. Podolak, K. Grabowska
- Biology, ChemistryPhytochemistry Reviews
- 8 October 2014
In this paper, literature data concerning chemistry and biological activity of steroidal saponins from the Allium genus has been reviewed.
Synergistic Cytotoxic and Anti-invasive Effects of Mitoxantrone and Triterpene Saponins from Lysimachia ciliata on Human Prostate Cancer Cells.
The synergy of proapoptotic activities of the analyzed cocktails is accompanied by their synergistic effects on prostate cancer cell movement and invasiveness, which confirms that the CIL-1/2 fraction might be considered a potent adjuvant for prostate cancer chemotherapy.
In vitro antifungal and cytotoxic activity of triterpene saponosides and quinoid pigments from Lysimachia vulgaris L.
Cytotoxic and antifungal activity of these compounds were tested in vitro against human and mouse melanoma cells and the yeast Candida albicans respectively and showed that saponoside B exerted cytotoxicity especially towards human melanoma Cells.
Flavonoid and phenolic acid profile by LC-MS/MS and biological activity of crude extracts from Chenopodium hybridum aerial parts
Abstract Extracts from leaves and stems of Chenopodium hybridum were characterised for the presence and quantity of flavonoids and phenolic acids by LC-ESI-MS/MS. Five flavonoids and eight phenolic…
Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies.
The inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations, which illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells.
Cytotoxic activity of embelin from Lysimachia punctata.
Enantioselective activity of usnic acid: a comprehensive review and future perspectives
This review is focused on the comparison of the biological and pharmacological activities of usnic acid enantiomers. Most of the available data refer to (+)-usnic acid, while the left-handed isomer…
Steroidal glycosides from the underground parts of Allium ursinum L. and their cytostatic and antimicrobial activity.
- D. Sobolewska, Z. Janeczko, W. Kisiel, I. Podolak, A. Galanty, D. Trojanowska
- Chemistry, BiologyActa poloniae pharmaceutica
- 1 May 2006
The spirostanol saponins mixture was investigated to determine its in vitro antimicrobal activity against Trichophyton mentagrophytes and Microsporum canis and the results of in vitro cytotoxic activity of the mixture of spirost-5-en-3b-ol tetrasaccharide are reported.