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The relevance of animal models in multiple sclerosis research.
None of the three main animal models of multiple sclerosis can be considered superior; rather, they are best viewed as complementary to one another. Expand
Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque
An extensive analysis of white matter plaques in a large sample of multiple sclerosis (MS) autopsies provides insights into the dynamic nature of MS pathology.
Gray matter involvement in multiple sclerosis
It remains likely that GM damage is related to WM damage, and continued studies of GM pathology as well as neuronal and axonal involvement in MS and related experimental models are necessary to better understand the etiology and pathogenesis of the degenerative components. Expand
Pathology of Multiple Sclerosis: Where Do We Stand?
The importance of developing imaging techniques able to capture early inflammatory cortical demyelination in MS is stressed in order to better understand the disease pathogenesis and to determine the impact of potential disease-modifying therapies on the cortex. Expand
Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis
Patients with RRMS do not inevitably develop a progressive disease course, and onset of progression is more dependent on age than the presence or duration of a pre-progression symptomatic disease course. Expand
The natural history of recurrent optic neuritis.
Patients with rapid succession of severe ON events are more likely to develop a generalized demyelinating disease and patients with NMO had a worse visual outcome. Expand
In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies
A novel MRI technique to image immune cell location and homing in vivo to the central nervous system (CNS) of mice infected with Theiler's murine encephalomyelitis virus and in mice with experimental autoimmune encephalomeelitis (EAE). Expand
Contrasting effects of IFNβ and IVIG in children with central and peripheral demyelination
Three children with MS who responded dramatically to interferon-β (IFNβ) therapy and developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration are reported. Expand
The thalamus and multiple sclerosis
The contention that neuropathologic and neuroimaging correlative investigations of thalamic derangements in MS may elucidate not heretofore considered pathobiological underpinnings germane to understanding the ontogeny, magnitude, and progression of the disease process is underscore. Expand
Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells
This study is the first to demonstrate that CNS infiltrating antigen-specific CD8 T cells have the capacity to initiate BBB tight junction disruption through a non-apoptotic perforin dependent mechanism and these novel findings are highly relevant to the development of therapies designed to control immune mediated CNS vascular permeability. Expand