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Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000Expand
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Combined CYP2C9, VKORC1 and CYP4F2 frequencies among racial and ethnic groups.
AIMS CYP4F2*3 (p.V433M) has been associated with higher warfarin dose requirements; however, its frequency, like other CYP2C9 and VKORC1 variants, has not been systematically assessed in majorExpand
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GeneCardsTM 2002: towards a complete, object-oriented, human gene compendium
MOTIVATION In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving,Expand
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Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE
Recent enhancements and current research in the GeneCards (GC) (http://bioinfo.weizmann.ac.il/cards/) project are described, including the addition of gene expression profiles and integrated geneExpand
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Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease.
RATIONALE Portopulmonary hypertension (PPHTN) occurs in 6% of liver transplant candidates. The pathogenesis of this complication of portal hypertension is poorly understood. OBJECTIVES To identifyExpand
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Diversified Microbiota of Meconium Is Affected by Maternal Diabetes Status
OBJECTIVES This study was aimed to assess the diversity of the meconium microbiome and determine if the bacterial community is affected by maternal diabetes status. METHODS The first intestinalExpand
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Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice
BackgroundApert syndrome is characterized by craniosynostosis and limb abnormalities and is primarily caused by FGFR2 +/P253R and +/S252W mutations. The former mutation is present in approximatelyExpand
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Fetomaternal Trafficking in the Mouse Increases as Delivery Approaches and Is Highest in the Maternal Lung1
Abstract The purpose of the study was to understand in more detail the natural history of fetomaternal cell trafficking in healthy pregnant mice. Our goal was to identify the best target organs andExpand
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Association between Estrogen receptor α gene variation and cardiovascular disease
ContextEstrogen and related hormone therapies activate estrogen receptors, which in turn regulate genes for several cardiovascular disease (CVD) risk factors. Relatively little is known, however,Expand
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A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9
Sagittal craniosynostosis is the most common form of craniosynostosis, affecting approximately one in 5,000 newborns. We conducted, to our knowledge, the first genome-wide association study forExpand
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