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Cluster analysis and clinical asthma phenotypes.
TLDR
Cluster analysis offers a novel multidimensional approach for identifying asthma phenotypes that exhibit differences in clinical response to treatment algorithms, and is specific to refractory asthma.
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
TLDR
New definitions for asthma control, severity, and exacerbations are developed, based on current treatment principles and clinical and research relevance, to provide a basis for a multicomponent assessment of asthma by clinicians, researchers, and other relevant groups in the design, conduct, and evaluation of clinical trials, and in clinical practice.
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019
TLDR
Blood eosinophils are recommended as a biomarker to support clinical decisions regarding the use of inhaled corticosteroids in chronic obstructive pulmonary disease patients, based on recent evidence from clinical trials.
Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)
TLDR
The Leicester Cough Questionnaire is a valid, repeatable 19 item self-completed quality of life measure of chronic cough which is responsive to change and should be a useful tool in clinical trials and longitudinal studies.
Mepolizumab treatment in patients with severe eosinophilic asthma.
TLDR
Mepolizumab administered either intravenously or subcutaneously significantly reduced asthma exacerbations and was associated with improvements in markers of asthma control and the safety profile of mepolIZumab was similar to that of placebo.
Mast-cell infiltration of airway smooth muscle in asthma.
TLDR
The infiltration of airway smooth muscle by mast cells is associated with the disordered airway function found in asthma.
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
TLDR
The results suggest the presence of a distinct subgroup of patients with mild to moderate asthma who have predominantly neutrophilic airway inflammation and who respond less well to treatment with inhaled corticosteroids.
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
TLDR
The heterogeneity of the biologic response of COPD exacerbations can be defined and biomarkers that differentiated clinical exacerbation phenotypes were investigated, including sputum IL-1β, serum CXCL10, and peripheral eosinophils are biomarkers of bacteria-, virus-, or eos inophil-associated exacerbations of COPd.
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