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Perinatal antidepressant exposure alters cortical network function in rodents
TLDR
It is shown that manipulation of 5-HT during early development in both in vitro and in vivo models disturbs characteristic chemoarchitectural and electrophysiological brain features, including changes in raphe and callosal connections, sensory processing, and myelin sheath formation. Expand
Neonatal Antidepressant Exposure has Lasting Effects on Behavior and Serotonin Circuitry
TLDR
It is shown that chronic neonatal exposure to citalopram results in profound reductions in both the rate-limiting serotonin synthetic enzyme and serotonin transporter expression in dorsal raphe and in cortex that persist into adulthood, indicating that the previously reported neurobehavioral effects of antidepressants are a consequence of their effects on the serotonin transporter. Expand
Glutamate and depression: clinical and preclinical studies.
TLDR
Recent data indicate that a single intravenous dose of an NMDA receptor antagonist is sufficient to produce sustained relief from depressive symptoms, and these findings represent exciting and novel avenues to both understand depressive symptomatology and develop more effective antidepressants. Expand
Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test.
TLDR
It is reported that NO synthase antagonists are as efficacious as imipramine in reducing the duration of immobility in the mouse forced swim test, and this data support the hypothesis that NO synthesis antagonists possess antidepressant properties and may represent a novel class of therapeutics for major depressive disorders. Expand
Neonatal Exposure of Rats to Antidepressants Affects Behavioral Reactions to Novelty and Social Interactions in a Manner Analogous to Autistic Spectrum Disorders
TLDR
It is concluded that neonatal exposure to antidepressants in rats results in sensory and social abnormalities that parallel many of those reported in ASD. Expand
Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.
TLDR
It is proposed that adaptive changes in NMDA receptors may be the final common pathway for antidepressant action. Expand
Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment.
TLDR
The present data support the hypothesis that some of the lasting behavioral abnormalities induced by early antidepressant exposure are sensitive to clinically relevant antidepressant treatments thus adding a measure of predictive validity to this paradigm as a model of these depressive symptoms. Expand
Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development
TLDR
The hypothesis that stimulation of serotonin autoreceptors during development contributes to the adult sexual deficit in rats neonatally exposed to citalopram is supported. Expand
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
TLDR
The ability of antidepressants drawn from every principal therapeutic class to effect adaptive changes in the N-methyl-D-aspartate receptor complex is consistent with the hypothesis that this ligand-gated ion channel serves as a final common pathway of antidepressant action and indicates that glutamatergic pathways may be involved in the pathophysiology of depression. Expand
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
TLDR
Findings indicate that adaptive changes in the NMDA receptor complex could be a feature common to chronic treatment with structurally unrelated antidepressants. Expand
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