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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungusExpand
The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin
Abstract. The metabolism of the fluoroquinolone drugs ciprofloxacin and norfloxacin by Pestalotiopsis guepini strain P-8 was investigated. Cultures were grown at 28 °C in sucrose/peptone broth for 18Expand
Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus
ABSTRACT Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed withExpand
Transformation of artemisinin by Cunninghamella elegans
Semi-synthetic derivatives of the anti-malarial drug artemisinin hold great promise in the search for an effective and economical treatment of chloroquine-resistant forms of malaria. Unfortunately,Expand
Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus
To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethylExpand
Biocatalysis of the Antimalarial Artemisinin by Mucor ramannianus. Strains
Abstract Biocatalysis of artemisinin by different strains of Mucor ramannianus.* illustrates a simple approach to bioengineering for attaining useful biotransformation strains for preparative orExpand
Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger
Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 daysExpand
Microbial transformation of antimalarial terpenoids.
The fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs forExpand
Biotransformation of Steroids and Flavonoids by Cultures of Aspergillus niger
Steroids are derivatives of the triterpenoid squalene, containing three fused cyclohexane rings and a cyclopentane ring, and flavonoids are derivatives of L-phenylalanine, containing two aromaticExpand
Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride
The formation of conjugates from two antibacterial fluoroquinolone drugs, ciprofloxacin and norfloxacin, was observed in cultures of Trichoderma viride that had been grown in sucrose-peptone brothExpand