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The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin
Abstract. The metabolism of the fluoroquinolone drugs ciprofloxacin and norfloxacin by Pestalotiopsis guepini strain P-8 was investigated. Cultures were grown at 28 °C in sucrose/peptone broth for 18Expand
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Transformation of artemisinin by Cunninghamella elegans
Semi-synthetic derivatives of the anti-malarial drug artemisinin hold great promise in the search for an effective and economical treatment of chloroquine-resistant forms of malaria. Unfortunately,Expand
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Microbial transformation of antimalarial terpenoids.
The fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs forExpand
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Biotransformation of Steroids and Flavonoids by Cultures of Aspergillus niger
Steroids are derivatives of the triterpenoid squalene, containing three fused cyclohexane rings and a cyclopentane ring, and flavonoids are derivatives of L-phenylalanine, containing two aromaticExpand
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Microbial transformation of azaarenes and potential uses in pharmaceutical synthesis
Pyridine, quinoline, acridine, indole, carbazole, and other heterocyclic nitrogen-containing compounds (azaarenes) can be transformed by cultures of bacteria and fungi to produce a variety of newExpand
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Biotransformation of N-acetylphenothiazine by fungi
Abstract Cultures of the fungi Aspergillus niger, Cunninghamella verticillata, and Penicillium simplicissimum, grown in a sucrose/peptone medium, transformed N-acetylphenothiazine toExpand
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Microbial transformations of antimicrobial quinolones and related drugs
The quinolones are an important group of synthetic antimicrobial drugs used for treating bacterial diseases of humans and animals. Microorganisms transform antimicrobial quinolones (includingExpand
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The use of Aspergillus niger cultures for biotransformation of terpenoids
Abstract Aspergillus niger is a well-known fungus that has been used for many different biotransformations of organic compounds. The terpenoids include a large variety of natural hydrocarbons andExpand
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Biotransformations of organic compounds mediated by cultures of Aspergillus niger
Many different organic compounds may be converted by microbial biotransformation to high-value products for the chemical and pharmaceutical industries. This review summarizes the use of strains ofExpand
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Transformation of saturated nitrogen-containing heterocyclic compounds by microorganisms
The saturated nitrogen-containing heterocyclic compounds include many drugs and compounds that may be used as synthons for the synthesis of other pharmacologically active substances. The need for newExpand
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