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Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics
TLDR
This study shows that CAVIar and BIMBAM are actually approximately equivalent to each other, and develops a fine-mapping method using marginal test statistics in the Bayesian framework, which is called CAVIAR Bayes factor (CAVIARBF). Expand
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results.
TLDR
Specific SNP associations between TLRs and their associated signaling molecules that have a known role in viral immunity and variations in both humoral and cellular immunity following measles vaccination are identified to understanding the immunogenetic mechanisms underlying variations in the immune response to measles vaccine. Expand
Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century.
TLDR
In this review, the immune response network theory and its application to the new field of vaccinomics and adversomics are discussed, and howvaccinomics can lead to new vaccine candidates, new understandings of how vaccines stimulate immune responses, new biomarkers for vaccine response, and facilitate the understanding of what genetic and other factors might be responsible for rare side effects due to vaccines. Expand
Frequency of Measles Virus-Specific CD4+ and CD8+ T Cells in Subjects Seronegative or Highly Seropositive for Measles Vaccine
TLDR
The detection of measles virus-induced IFN-γ and IL-4 production by ELISPOT can be used to identify measlesirus-specific low-frequency memory T cells in subjects immunized with measles vaccine and differences agree in directionality with the observed antibody response phenotype. Expand
Immunosenescence and human vaccine immune responses
TLDR
The functional changes that are known to occur in the adaptive immune system with age are highlighted, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. Expand
Immunogenetics of seasonal influenza vaccine response.
TLDR
It is proposed that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines. Expand
Personalized vaccines: the emerging field of vaccinomics.
TLDR
The basis and logic of personalized vaccines are reviewed, recent advances are described, and newly available data suggest that some vaccine-related adverse events may also be genetically determined and, therefore, predictable. Expand
Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.
TLDR
Specific SNPs in the cytokine and cytokine receptor genes are significantly associated with variations in measures of the immune response to measles vaccination. Expand
The weight of obesity on the human immune response to vaccination.
TLDR
The immune system is adversely affected by obesity, and these "immune consequences" raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected. Expand
Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors.
TLDR
Specific SNPs present in both the SLAM and CD46 genes are associated with measurable and significant variations in antibody response after measles vaccination, which is important to better understand variations in immune responses to vaccines and to design better vaccines. Expand
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