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Spectroscopic study of human lung epithelial cells (A549) in culture: living cells versus dead cells.
The noninvasive analysis of living cells grown on 3-dimensional scaffold materials is a key point in tissue engineering. In this work we show the capability of Raman spectroscopy for use as aExpand
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Raman Spectroscopy Cell-based Biosensors
One of the main challenges faced by biodetection systems is the ability to detect and identify a large range of toxins at low concentrations and in short times. Cell-based biosensors rely onExpand
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Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy
A Raman spectroscopy cell-based biosensor has been proposed for rapid detection of toxic agents, identification of the type of toxin and prediction of the concentration used. This technology allowsExpand
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In situ spectral monitoring of mRNA translation in embryonic stem cells during differentiation in vitro.
Raman microspectroscopy was used to determine biochemical markers during the differentiation of embryonic murine stem cells (mES) in vitro. Such markers are useful to determine the differentiationExpand
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Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy
Significance Histopathology is the standard method for diagnosis of cancer. However, this method requires time-consuming procedures for sectioning and staining of tissues, making histopathologyExpand
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Raman spectroscopy for medical diagnostics--From in-vitro biofluid assays to in-vivo cancer detection.
Raman spectroscopy is an optical technique based on inelastic scattering of light by vibrating molecules and can provide chemical fingerprints of cells, tissues or biofluids. The high chemicalExpand
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Raman microspectroscopy: a noninvasive tool for studies of individual living cells in vitro
There is an increasing need for noninvasive methods that are able to monitor individual live cells in vitro, including in vitro testing of chemicals and pharmaceuticals, monitoring the growth ofExpand
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In situ monitoring of cell death using Raman microspectroscopy.
We investigated the use of Raman microspectroscopy to monitor the molecular changes in human lung carcinoma epithelial cells (A549) when cell death was induced by a toxic chemical. We treated A549Expand
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Preparation, characterization, and in vitro degradation of bioresorbable and bioactive composites based on Bioglass-filled polylactide foams.
Highly porous poly(D,L-lactide)/Bioglass composites scaffolds were prepared by thermally induced phase separation process of polymer solutions and subsequent solvent sublimation. A series ofExpand
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New detection system for toxic agents based on continuous spectroscopic monitoring of living cells.
In this study, we show the feasibility of a new type of cell based biosensor which uses spectroscopic in situ real time detection of biochemical changes in living cells exposed to toxic chemicalExpand
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