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The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats.
It was demonstrated that a three-day pretreatment with either GL or GA exhibited protective effect on retrorsine-induced liver damage in rats, and extensive hepatocellular damages were observed. Expand
A randomised phase II study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with
Treatment with ustekinumab or guselkumab did not significantly reduce the signs and symptoms of RA and no new safety findings were observed with either treatment. Expand
Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.
Novel (+/-)-4-azolyl retinoic acid analogues 4, 5, 7 and 8 have been designed and synthesized and have been shown to be powerful inhibitors of hamster microsomal all-trans-retinoic acid 4-hydroxylaseExpand
Pharmacokinetics of trimethylamine in rats, including the effects of a synthetic diet
  • I. Nnane, L. Damani
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 1 January 2001
The altered pharmacokinetic profile of TMA and its N -oxide suggest a diminished drug-elimination capacity in rat placed on the synthetic diet and dietary modulation of flavin-containing monooxygenase (FMO) activity may explain the effects of diet on the pharmacokinetics. Expand
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats
It is suggested that single oral doses of TAM delay the absorption of letrozole while chronic pretreatment with TAM accelerates the elimination of let rozole, probably due to induction of cytochrome P450 enzymes in rats. Expand
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17α-Hydroxylase-C17,20-lyase (P45017α) : Potential agents for the treatment of prostate cancer
A new synthetic route to a variety of novel delta 16-17-azolyl steroids is described: it involves the nucleophilic vinylic "addition-elimination" substitution reaction of 3Expand
Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer.
Results show that some of the compounds initially developed to be inhibitors of androgen synthesis also interact with the human AR and modulate the proliferation of hormone-dependent prostatic cancer cells and hold promise for the treatment of androgens-dependent prostate tumors. Expand
Development and validation of stability indicating high-performance liquid chromatographic assays for ketotifen in aqueous and silicon oil formulations
SummaryA simple and specific high-performance liquid chromatographic (HPLC) method for the analysis of ketotifen in aqueous solutions and silicon oil suspensions is described. The HPLC system isExpand
CC-chemokine ligand 2 inhibition in idiopathic pulmonary fibrosis: a phase 2 trial of carlumab
It is unlikely that carlumab provides benefit to patients with idiopathic pulmonary fibrosis, and SGRQ scores showed a nonsignificant trend toward worsening with active treatment. Expand
Effects of new 17α-hydroxylase/C17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo
Two new inhibitors of a key regulatory enzyme of testicular and adrenal androgen synthesis 17α-hydroxylase/C17,20-lyase (P450c17) are suggested to be potential candidates for treatment of prostate cancer. Expand