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Sustained stress response after oxidative stress in trabecular meshwork cells
Purpose To investigate the mechanisms by which chronic oxidative stress may lead to a sustained stress response similar to that previously observed in the trabecular meshwork (TM) of glaucoma donors.Expand
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Human aqueous humor exosomes.
Aqueous humor (AH) is a dynamic intraocular fluid that supports the vitality of tissues that regulate intraocular pressure. We recently discovered that extracellular nanovesicles called exosomes areExpand
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Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma
Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been linked to decreased conventional outflow of aqueous humor (AH). To better understand the molecular changes in the AHExpand
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Pigment epithelium-derived factor decreases outflow facility.
PURPOSE Pigment epithelium-derived factor (PEDF) regulates blood-retinal barrier function. As a constituent of aqueous humor, the role of PEDF in conventional outflow function is unknown. The goalsExpand
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In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model
Significance Glaucoma is the leading cause of irreversible blindness worldwide. The primary and only modifiable risk factor for the development of glaucoma is elevated intraocular pressure (IOP), andExpand
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LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma
Purpose To study lysyl oxidase-like 1 (LOXL1) expression in freshly collected lens capsules from pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and normal cataract controlExpand
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Differential response and withdrawal profile of glucocorticoid‐treated human trabecular meshwork cells
Abstract The goal of the study was to examine secreted protein response and withdrawal profiles from cultured human trabecular meshwork (HTM) cells following short‐ and long‐term glucocorticoidExpand
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Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes.
Visual impairment due to glaucoma currently impacts 70 million people worldwide. While disease progression can be slowed or stopped with effective lowering of intraocular pressure, current medicalExpand
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Toward development of a point-of-care assay of enoxaparin anticoagulant activity in whole blood
There is need for a rapid assay to determine the efficacy of low-molecular-weight-heparin (LMWH) in whole blood. Heparinase was used to eliminate, and thereby quantify, the anticoagulant activity ofExpand
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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
Purpose The nitric oxide (NO)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway regulates aqueous humor outflow and therefore, intraocular pressure. We investigated the pharmacologic effects of theExpand
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