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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in… Expand
A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin
- G. M. Thomas, S. Frame, M. Goedert, I. Nathke, P. Polakis, P. Cohen
- Biology, Medicine
- FEBS letters
- 17 September 1999
The Axin‐dependent phosphorylation of β‐catenin catalysed by glycogen synthase kinase‐3 (GSK3) is inhibited during embryogenesis. This protects β‐catenin against ubiquitin‐dependent proteolysis,… Expand
Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol
Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling is well established as a central… Expand
THE ADENOMATOUS POLYPOSIS COLI PROTEIN: The Achilles Heel of the Gut Epithelium
- I. Nathke
- 8 October 2004
▪ Abstract The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the… Expand
Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway.
Although lymphoid enhancer binding factor-1 (Lef-1) plays an obligatory role in airway submucosal gland (SMG) development, its expression alone is not an adequate signal for initiating gland… Expand
Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling
It has been suggested that synapse-associated protein of 97-kDa molecular weight (SAP97) is a susceptibility factor for childhood and adult neuropsychiatric disorders. SAP97 is a scaffolding protein… Expand
SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo
Abstract The dendritic tree is a key determinant of neuronal information processing. In the motor system, the dendritic tree of spinal cord neurons undergoes dramatic remodeling in an… Expand
The cadherin/catenin complex: connections to multiple cellular processes involved in cell adhesion, proliferation and morphogenesis
Cadherins comprise a large family of membrane glycoproteins that mediate Ca+-dependent cell adhesion during development and in the adult. Although the extracellular domain controls homotypic… Expand
The adenomatous polyposis coli protein.
- I. Nathke
- 1 August 1999
Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will… Expand
Microultrasound characterisation of ex vivo porcine tissue for ultrasound capsule endoscopy
Gastrointestinal (GI) disease development and progression is often characterised by cellular and tissue architectural changes within the mucosa and sub-mucosa layers. Current clinical capsule… Expand