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Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance1
TLDR
Evidence is provided that absence of MyD88 promotes inducible allograft acceptance and implies that inhibiting innate immunity may be a potential, clinically relevant strategy to facilitate transplantation tolerance.
Modulation of ultraviolet‐induced hyperalgesia and cytokine upregulation by interleukins 10 and 13
TLDR
The hyperalgesia and cytokine upregulation induced by UVB and their modulation by antiinflammatory cytokines were characterized to show a biphasic temporal evolution with an acute phase and a late phase, since both were prevented by treatment with anti inflammatory cytokines.
Lymphoid Neogenesis in Murine Cardiac Allografts Undergoing Chronic Rejection
TLDR
The findings indicate that, like autoimmunity, alloimmunities is associated with lymphoid neogenesis in the target organ and suggest a role for local T‐cell activation in chronic allograft rejection.
Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue1
TLDR
It was found that CD8 memory T cells reject intratesticular grafts at a significantly slower rate than the rejection of intrarenal grafts, and delayed graft rejection in the testis was not due to reduced homing or proliferation of memory T cell but due to their increased apoptosis at that site.
Acute traumatic coagulopathy in a critically injured pediatric population: Definition, trend over time, and outcomes
TLDR
Elevated admission INR, elevated INR at 24 hours, and overall trend in INR strongly predict mortality in a diverse pediatric trauma population; however, product transfusion did not influence the INR trend or clinical outcome.
Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts
TLDR
Lymphoid neogenesis and TLO formation can be uniformly found in experimental and human VCA and PNAd expression in vascular endothelium correlates with skin rejection and T‐ and B‐cell infiltration.
Comparison of two regimens of beta-adrenergics in acute asthma.
TLDR
Three treatments in the first hour, and hourly thereafter showed no benefit over treatments initially, at onehour, and every other hour in acute, moderate, or severe exacerbation of asthma.
Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells 1
TLDR
Novel mechanisms of immune privilege are revealed and direct evidence that testicular immune privilege fosters the induction of transplantation tolerance to allografts in both immunologically privileged and non-privileged sites is provided.
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