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Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3*
TLDR
YB-1 counter-represses TGF-β-stimulated COL1A2 transcription by interfering with Smad3 bound to the upstream sequence around –265 and subsequently by interrupting the Smad 3-p300 interaction, providing a novel insight into the mechanism by which IFN-γ/YB -1 counteracts T GF-β/Smad3. Expand
Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human α2(I) Collagen Gene Expression by Interferon-γ*
TLDR
This study represents the definitive identification of the transcription factor responsible for IFN-γ-elicited inhibition of COL1A2 expression, namely YB-1. Expand
Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
TLDR
YB-1 counter-represses TGF-beta-stimulated COL1A2 transcription by interfering with Smad3 bound to the upstream sequence around -265 and subsequently by interrupting the Smad2-p300 interaction, which provides a novel insight into the mechanism by which IFN-gamma/YB1 counteracts T GF-beta/Smad3. Expand
Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.
TLDR
This study represents the definitive identification of the transcription factor responsible for IFN-gamma-elicited inhibition of COL1A2 expression, namely YB-1. Expand
An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes.
A metabolic activation system with an S9 fraction or liver microsomes was applied to a reporter gene assay in vitro for the screening of estrogenicity of chemicals. The endpoint (luciferase) wasExpand
Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d‐allethrin
TLDR
The neonatal exposure to d‐allethrin by inhalation did not induce effects either on the brain MAChR density and motor activity at 17 days and 4 months or on performance in the learning/memory test at the age of 11 months. Expand
Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
TLDR
None of the pyrethroids tested showed significant (p < 0.05) estrogenic or antiestrogenic effects (100 nM-10 microM), indicating that they do not impact on the classic hER alpha-mediated activation pathway in vitro. Expand
Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays.
TLDR
Evaluated the interaction of three pyrethroids with androgen receptor (AR)- and estrogen receptor (ER)-mediated mechanisms using in vivo short-term assays and concluded that none of esfenvalerate, fenavalerate, or permethrin exhibit any potential to cause adverse (anti-) androgenic or estrogenic effects at dose levels below that of those causing excessive systemic toxicity. Expand
Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity.
TLDR
Results strongly suggest that in the case of medazepam, cloxazolam and oxazol am, their metabolites may bind to receptor sites in the brain and then elicit pharmacological action. Expand
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