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- Publications
- Influence
Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3*
- K. Higashi, Y. Inagaki, K. Fujimori, A. Nakao, H. Kaneko, I. Nakatsuka
- Biology
- Journal of Biological Chemistry
- 31 October 2003
Transforming growth factor-β (TGF-β) and interferon-γ (IFN-γ) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding protein YB-1… Expand
Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human α2(I) Collagen Gene Expression by Interferon-γ*
- K. Higashi, Y. Inagaki, +4 authors I. Nakatsuka
- Biology
- The Journal of Biological Chemistry
- 14 February 2003
We have demonstrated previously that a proximal element within the human α2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-γ (IFN-γ), and designated this region… Expand
Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.
- K. Higashi, Y. Inagaki, +4 authors I. Nakatsuka
- Medicine
- The Journal of biological chemistry
- 2003
We have demonstrated previously that a proximal element within the human alpha2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-gamma (IFN-gamma), and designated… Expand
Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
- K. Higashi, Y. Inagaki, K. Fujimori, A. Nakao, H. Kaneko, I. Nakatsuka
- Medicine
- The Journal of biological chemistry
- 2003
Transforming growth factor-beta (TGF-beta) and interferon-gamma (IFN-gamma) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding… Expand
An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes.
- K. Sumida, N. Ooe, +4 authors I. Nakatsuka
- Medicine, Biology
- Biochemical and biophysical research…
- 12 January 2001
A metabolic activation system with an S9 fraction or liver microsomes was applied to a reporter gene assay in vitro for the screening of estrogenicity of chemicals. The endpoint (luciferase) was… Expand
Identification of a new non-functional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codon.
- K. Komai, K. Sumida, H. Kaneko, I. Nakatsuka
- Biology, Medicine
- Pharmacogenetics
- 1 February 1996
Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d‐allethrin
- R. Tsuji, Kumiko Kobayashi, +7 authors S. Kishioka
- Medicine
- Journal of applied toxicology : JAT
- 1 November 2002
Synthetic pyrethroids are among the most common pesticides and insecticides currently in worldwide use. Eriksson and co‐workers postulated that oral exposure of mice to pyrethroids during a neonatal… Expand
Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
- K. Saito, Y. Tomigahara, N. Ohe, N. Isobe, I. Nakatsuka, H. Kaneko
- Medicine, Biology
- Toxicological sciences : an official journal of…
- 1 September 2000
Estrogenic and antiestrogenic activity of pyrethroid insecticides (d-trans-allethrin, cypermethrin, empenthrin, fenvalerate, imiprothrin, permethrin, d-phenothrin and prallethrin) was evaluated using… Expand
Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays.
- T. Kunimatsu, T. Yamada, +5 authors I. Nakatsuka
- Medicine
- Regulatory toxicology and pharmacology : RTP
- 1 April 2002
Synthetic pyrethroids are among the most common pesticides and insecticides currently in use worldwide. Recently, chemicals classified as synthetic pyrethroids are suspected as being endocrine… Expand
Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity.
- I. Nakatsuka, H. Shimizu, Y. Asami, T. Katoh, A. Hirose, A. Yoshitake
- Chemistry, Medicine
- Life sciences
- 14 January 1985
Experiments were carried out to study the relationship between binding affinity to the benzodiazepine receptor and pharmacological activity, especially anti-anxiety activity, of clinically useful… Expand