I. Nakatsuka

Publications133
h-index18
Citations1,197
Highly Influential Citations36
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Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3*
Transforming growth factor-β (TGF-β) and interferon-γ (IFN-γ) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding protein YB-1… Expand
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Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human α2(I) Collagen Gene Expression by Interferon-γ*
We have demonstrated previously that a proximal element within the human α2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-γ (IFN-γ), and designated this region… Expand
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Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.
We have demonstrated previously that a proximal element within the human alpha2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-gamma (IFN-gamma), and designated… Expand
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Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
Transforming growth factor-beta (TGF-beta) and interferon-gamma (IFN-gamma) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding… Expand
  • 68
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An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes.
A metabolic activation system with an S9 fraction or liver microsomes was applied to a reporter gene assay in vitro for the screening of estrogenicity of chemicals. The endpoint (luciferase) was… Expand
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Identification of a new non-functional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codon.
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Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d‐allethrin
Synthetic pyrethroids are among the most common pesticides and insecticides currently in worldwide use. Eriksson and co‐workers postulated that oral exposure of mice to pyrethroids during a neonatal… Expand
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Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
Estrogenic and antiestrogenic activity of pyrethroid insecticides (d-trans-allethrin, cypermethrin, empenthrin, fenvalerate, imiprothrin, permethrin, d-phenothrin and prallethrin) was evaluated using… Expand
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Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays.
Synthetic pyrethroids are among the most common pesticides and insecticides currently in use worldwide. Recently, chemicals classified as synthetic pyrethroids are suspected as being endocrine… Expand
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Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity.
Experiments were carried out to study the relationship between binding affinity to the benzodiazepine receptor and pharmacological activity, especially anti-anxiety activity, of clinically useful… Expand
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