I. Najm

Publications309
h-index60
Citations13,401
Highly Influential Citations623
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The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission 1
Purpose:  Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of… Expand
Terminology and classification of the cortical dysplasias
Background: There have been difficulties in achieving a uniform terminology in the literature regarding issues of classification with respect to focal cortical dysplasias (FCDs) associated with… Expand
Functional connectivity in the human language system: a cortico-cortical evoked potential study.
TLDR
The present study revealed a bidirectional connection between Broca's and Wernicke's areas probably through the arcuate fasciculus and/or the cortico-subcortico-cortical pathway, which suggests that perisylvian and extrasylVian language areas participate in the language system as components of a network by means of feed-forward and feed-back projections. Expand
Surgical outcome and prognostic factors of frontal lobe epilepsy surgery.
TLDR
More than half of patients in favourable prognostic categories were seizure-free at 3 years, and up to 40% were seizure free at 5 years, compared to <15% in those with unfavourable outcome predictors, which underscores the importance of appropriate selection of potential surgical candidates. Expand
Complications of invasive video-EEG monitoring with subdural grid electrodes
TLDR
Improvements in grid technology, surgical technique, and postoperative care resulted in significant reductions in the complication rate, and no association with complications was found for number of seizures, IQ, anticonvulsants, or grid localization. Expand
The epileptogenic zone: general principles.
TLDR
Sir Victor Horsley, a British neurosurgeon, pioneered epilepsy surgery and, in 1886, published the reports of successful cortical resections that resulted in a significant reduction in epileptic seizures in three patients. Expand
Seizure‐Promoting Effect of Blood–Brain Barrier Disruption
TLDR
It is generally accepted that blood–brain barrier (BBB) failure occurs as a result of CNS diseases, including epilepsy, but evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures. Expand
The localizing value of ictal EEG in focal epilepsy
TLDR
With the exception of mesial frontal lobe epilepsy, ictal recordings are very useful in the localization/lateralization of focal seizures, and some patterns are highly accurate in localizing the epileptogenic lobe. Expand
Electro-clinical and imaging characteristics of focal cortical dysplasia: Correlation with pathological subtypes
TLDR
Clinically important differences exist between the pathological subtypes of CD, which may assist in their management, and provide further insight into their underlying pathophysiology. Expand
Antagonism of peripheral inflammation reduces the severity of status epilepticus
TLDR
The hypothesis that intravenous administration of IL-1 receptor antagonists (IL-1ra) may prevent pilocarpine-induced seizures is tested and the concept of targeting systemic inflammation and BBB for the prevention of status epilepticus is supported. Expand
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