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RNA granules in germ cells.
"Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins andExpand
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Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway
TISP40, a mouse spermatid‐specific gene, encodes a CREB/CREM family transcription factor that is predominantly expressed during spermiogenesis. We report here that TISP40 generates two types ofExpand
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GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression
Cyclin G-associated kinase (GAK) is an association partner of clathrin heavy chain (CHC) and is essential for clathrin-mediated membrane trafficking. Here, we report two novel functions of GAK:Expand
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Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation.
Mammalian spermiogenesis, a process where haploid male germ cells differentiate to become mature spermatozoa, entails dramatic morphological and biochemical changes including remodeling of the germExpand
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SirT1 is required in the male germ cell for differentiation and fecundity in mice
Sirtuins are NAD+-dependent deacylases that regulate numerous biological processes in response to the environment. SirT1 is the mammalian ortholog of yeast Sir2, and is involved in many metabolicExpand
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Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients
Vasculitis (angiitis) is a systemic autoimmune disease that often causes fatal symptoms. We aimed to isolate cDNA markers that would be useful for diagnosing not only vasculitis but also otherExpand
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PNLDC1, mouse pre‐piRNA Trimmer, is required for meiotic and post‐meiotic male germ cell development
PIWI‐interacting RNAs (piRNAs) are germ cell‐specific small RNAs essential for retrotransposon gene silencing and male germ cell development. In piRNA biogenesis, the endonuclease MitoPLD/ZucchiniExpand
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Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
We have comprehensively identified the genes whose expressions are augmented in bone marrow-derived mononuclear cells (BMMC) from patients with Rheumatoid Arthritis (RA) as compared with BMMCs fromExpand
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The testes‐specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis
We previously reported that the spermatid‐specific transcription factor Tisp40 functions through UPRE and CRE. To investigate Tisp40 function in vivo, we generated TISP40(–/–) mice. TISP40(–/–) miceExpand
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The chromatoid body of male germ cells: Epigenetic control and miRNA pathway
Differentiation of germ cells is characterized by a remarkable degree of cellular restructuring and gene regulation that involves complex events of genomic and epigenetic reorganization. The pathwaysExpand
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