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The open channel blocking drug, IEM-1460, reveals functionally distinct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors in rat brain neurons
The properties of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors were examined in various cell types isolated from young rat hippocampus, striatum and cerebellum usingExpand
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Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460
Dicationic adamantane derivative, IEM-1460, which selectively blocks GluR2-lacking, Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors, was used to characterize theExpand
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Histamine potentiates N-methyl-d-aspartate responses in acutely isolated hippocampal neurons
N-methyl-D-aspartate (NMDA)-evoked currents were recorded from acutely isolated rat hippocampal neurons, using the whole-cell patch-clamp technique and a rapid perfusion system. Histamine, atExpand
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High‐affinity copper block of GABAA receptor‐mediated currents in acutely isolated cerebellar Purkinje cells of the rat
The actions of Cu2+ ions on GABAA receptor‐mediated currents in acutely isolated Purkinje cells from rat cerebellum were studied using the whole‐cell patch‐clamp technique and a rapid perfusionExpand
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Differential modulation of AMPA receptors by cyclothiazide in two types of striatal neurons
The modulation of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazol‐propionate (AMPA) receptor‐mediated currents by cyclothiazide was investigated in acutely isolated cells from rat striatum with whole‐cellExpand
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GABAA receptor heterogeneity in histaminergic neurons
Histaminergic neurons of the tuberomamillary nucleus display pacemaker properties; their firing rate is regulated according to behavioural state by gabaergic inhibition. Whole‐cell recordings andExpand
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A simple perfusion system for patch-clamp studies
Many systems for rapid perfusion of isolated cells or membrane patches operate with separate capillaries for each drug to be applied. We describe here a simple way by which the solutions in a singleExpand
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Tetrahydroaminoacridine blocks and prolongs NMDA receptor-mediated responses in a voltage-dependent manner.
N-Methyl-D-aspartate (NMDA) receptor-mediated currents were recorded from acutely isolated rat hippocampal neurones using patch-clamp and fast perfusion techniques. Tetrahydroaminoacridine blockedExpand
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Block of GABAA receptor ion channel by penicillin: Electrophysiological and modeling insights toward the mechanism
GABA(A) receptors (GABA(A)R) mainly mediate fast inhibitory neurotransmission in the central nervous system. Different classes of modulators target GABA(A)R properties. Penicillin G (PNG) belongs toExpand
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Subcortical modulation of synaptic plasticity in the hippocampus
A two-stage model of memory trace formation in the hippocampus considers exploratory behavior associated with theta activity and consumatory behaviors or immobility associated with the occurrence ofExpand
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