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Strategies in the designing of prodrugs, taking into account the antiviral and anticancer compounds.
Methods of discovering new structures or modifications of known structures and their synthesis as well as new therapeutic strategies using prodrugs are indicated, which are expected to be successful and to broaden the knowledge on what is happening to the drug in the body, in addition to providing a molecular explanation of xenobiotics activity. Expand
Calculation procedures and HPLC method for analysis of the lipophilicity of acyclovir esters
It was proved that the AC log P algorithm can be useful for the analysis of these compounds and has a statistically justified application in the assessment of the quantitative structure–activity relationship. Expand
Ester groups as carriers of antivirally active tricyclic analogue of acyclovir in prodrugs designing: synthesis, lipophilicity--comparative statistical study of the chromatographic and theoretical
It was proved that the AC logP algorithm can be useful for the analysis of these compounds, which can have a statistically justified application in the assessment of the quantitative structure- activity relationship (QSAR). Expand
A validated spectrophotometric and liquid chromatography method for determination and purity evaluation of
Kinetic studies of the decomposition process of I in both acidic and alkaline environments indicate instability of the imide group, as indicated by the results of spectrophotometric analysis. Expand
Analysis of Sartans: a review.
This review is concerned with methods for the analysis of sartans in various matrices, such as pharmaceutical formulations, environmental and biological samples, and discusses the current status of stability studies of sARTans. Expand
New Molecular Targets of Anticancer Therapy - Current Status and Perspectives.
The paper discusses the molecular targets and chemical structure of target anticancer drugs that have been approved for and currently applied in antineoplastic therapy together with indications and contraindications for their application. Expand
Hepatitis C - New drugs and treatment prospects.
The molecular targets and chemical structures of drugs used in HCV treatment are reviewed andications and contraindications for anti-HCV drugs are also discussed together with application regimens. Expand
The mechanism of ceftazidime degradation in aqueous solutions.
The decomposition of ceftazidime and the formation and identification of product C (pyridine) was followed by HPLC and the hydrolysis of the group at C-3, opening of the beta-lactam ring, and epimerization atC-6 or C-7. Expand
1,2-Naphthoquinone-4-sulfonic acid sodium salt as a reagent for spectrophotometric determination of rimantadine and memantine
A selective ultraviolet and visible spectrophotometric method (UV-Vis) for the determination of memantine (MM) and rimantadine (RM) hydrochlorides after derivatization withExpand
Determination of adamantane derivatives in pharmaceutical formulations by using spectrophotometric UV-Vis method
The proposed method could be applied to the determination of AM, MM and RM in dosage forms and the recovery was 95.3–101.9%. Expand