• Publications
  • Influence
Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.
The new 3,4-secotriterpene acid 20-epi-koetjapic acid (5) potently inhibited rat neonatal brain microglia phorbol ester-stimulated thromboxane B(2) and superoxide anion (IC(50) = 1.9 microM) generation.
New alkamides from maca (Lepidium meyenii).
Five new alkamides have been found from only L. meyenii and could be used as markers for authentication and standardization and the identity of N-benzyl-15Z-tetracosenamide was confirmed by synthesis.
Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide
The synergistic activity of antimycobacterial constituents from Saudi plants was evaluated in combination with isonicotinic acid hydrazide (INH) against four atypical organisms, namely, Mycobacterium
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
Compounds 1, 4, and 5 demonstrated in vitro antimalarial activity against Plasmodium falciparum (W-2 clone), while 2 was inactive and 2 showed in vitro cytotoxicity to selected human cancer cell lines (IC50 = 3-6 microg/mL against SK-MEL, KB, BT-549, and SK-OV-3), and 4 was also cytotoxic to human malignant melanoma.
Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatography.
The first analytical method allowing the determination of the main macamides and macaenes, the marker compounds of L. meyenii is described, demonstrating accuracy, precision, linearity, limit of detection and intra/inter day repeatability.
Antiparasitic alkaloids from Psychotria klugii.
Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 and Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive.
New constituents from noni (Morinda citrifolia) fruit juice.
Morinda citrifolia L. (Rubiaceae), known as noni, has a long history of traditional use in the Hawaiian and Tahitian islands. More recently, an array of commercial noni fruit juice products are
Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.
A new potent antiinfective and antiparasitic 2,3-dihydro-1H-indolizinium chloride (1) was isolated from Prosopis glandulosa var. glandulosa. Three additional new (2-4) and one known (5) indolizidines