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Clinical and molecular characterization of a cohort of 161 unrelated women with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency and 330 family members.
TLDR
The study of family members underlines the variable expression of NC-CAH even within a family, suggesting that modifier factors may modulate phenotype expression. Expand
Immortalization of human adult normal prostatic epithelial cells by liposomes containing large T-SV40 gene.
TLDR
For the first time to the authors' knowledge, the immortalization of normal adult prostatic epithelial cells in culture by transfection of a plasmid containing SV40 genome with a defective replication origin encapsulated into liposomes is reported. Expand
Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme.
TLDR
Nine additional mutations in the 5alpha-reductase 2 gene in subjects with 5 alpha- reductase deficiency are described, providing insight into functional domains in the protein as well as an unusual acidic pH optimum characteristic of the 5Alpha-Reductase type 2 isozyme. Expand
Natural mutagenesis study of the human steroid 5α-reductase 2 isozyme
TLDR
Nine additional mutations in the 5alpha-reductase 2 gene in subjects with 5 alpha- reductase deficiency are described, providing insight into functional domains in the protein as well as an unusual acidic pH optimum characteristic of the 5Alpha-Reductase type 2 isozyme. Expand
Tamoxifen and hydroxytamoxifen isomers versus estradiol effects on normal human breast cells in culture.
TLDR
The presence andEstradiol dependence of ER have been demonstrated in HBE cells, which constitute a fruitful model for the study of hormone/antihormone actions, and in these normal cells, estradiol stimulates growth, whereas TAM and the 4OHTAM isomers are potent inhibitors of cell multiplication, as they are in breast cancer cell lines in culture. Expand
Estradiol and progesterone receptors in cultured normal human breast epithelial cells and fibroblasts: immunocytochemical studies.
TLDR
In normal breast epithelial cells, E2 stimulates both its own receptor and PR, whereas the progestin R5020 lowers ER andPR content, in contrast, ER and PR content in normal breast fibroblasts seem to be independent of E2 or P action. Expand
Alterations of expression and regulation of transforming growth factor β in human cancer prostate cell lines
TLDR
Prostate cancer cell lines have lost part of their ability to secrete and activate TGF beta, and to regulate this secretion through stromal-epithelial interactions, and androgen-sensitive cancer cells may compensate this loss by hormonal regulation. Expand
The effect of progestins on submaxillary gland epidermal growth factor: demonstration of androgenic, synandrogenic and antiandrogenic actions.
TLDR
The data indicate that progestins as a class are capable of androgenic, synandrogenic and antiandrogens action in the mouse submaxillary gland, but that no single progestin is capable of all three actions. Expand
Late-onset adrenal hyperplasia in hirsutism.
TLDR
The role of skin sensitivity to androgens is important in determining the clinical expression of this disorder, and a high correlation between late-onset adrenal hyperplasia and HLA antigens B14 and Aw33 is found. Expand
Androgen metabolism in hirsute patients treated with cyproterone acetate.
TLDR
CPA acts through several mechanisms: (1) it lowers the androgen input to the target cells by depressing T production through its antigonadotropic effect and (b) accelerating T metabolic inactivation due to a partial enzymatic inducer effect on the liver. Expand
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