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- Publications
- Influence
CXCL13 production in B cells via Toll-like receptor/lymphotoxin receptor signaling is involved in lymphoid neogenesis in chronic obstructive pulmonary disease.
- Eleni Litsiou, M. Semitekolou, +11 authors M. Tsoumakidou
- Biology, Medicine
- American journal of respiratory and critical care…
- 1 June 2013
RATIONALE
Little is known about what drives the appearance of lymphoid follicles (LFs), which may function as lymphoid organs in chronic obstructive pulmonary disease (COPD). In animal infection… Expand
Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand.
- M. Tsoumakidou, Sofia Tousa, +12 authors G. Xanthou
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 October 2014
BACKGROUND
Increased mortality rates in patients with chronic obstructive pulmonary disease (COPD) are largely due to severe infectious exacerbations. Impaired respiratory immunity is linked to the… Expand
Dendritic cells conditioned by activin A–induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma
- M. Semitekolou, I. Morianos, +4 authors G. Xanthou
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 June 2017
Background: Previously, we demonstrated that regulatory T (Treg) cells induced by the cytokine activin‐A suppress TH2‐mediated allergic responses and linked airway disease. Still, the effects of… Expand
Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
- Sofia Tousa, M. Semitekolou, +12 authors G. Xanthou
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 20 March 2017
Significance Here, we demonstrate that the cytokine activin-A instructs the differentiation of human IL-10–producing type 1 regulatory T (Tr1)-like cells that exhibit strongly suppressive functions… Expand
Innate immunity as the orchestrator of allergic airway inflammation and resolution in asthma.
- Despoina Thiriou, I. Morianos, G. Xanthou, K. Samitas
- Biology, Medicine
- International immunopharmacology
- 1 July 2017
The respiratory system is constantly in direct contact with the environment and, has therefore, developed strong innate and adaptive immune responses to combat pathogens. Unlike adaptive immunity… Expand
Characterization of intracellular HLA-DR, DM and DO profile in K562 and HL-60 leukemic cells.
- Lina Papadimitriou, I. Morianos, V. Michailidou, E. Dionyssopoulou, S. Vassiliadis, I. Athanassakis
- Biology, Medicine
- Molecular immunology
- 1 September 2008
Surface class-II antigen expression fires-up the antigen presentation process and development of immune response. The absence of surface HLA-DR is used in various systems to avoid immune recognition.… Expand
Comparative analysis of FV vectors with human α- or β-globin gene regulatory elements for the correction of β-thalassemia
- I. Morianos, E. K. Siapati, G. Pongas, G. Vassilopoulos
- Biology, Medicine
- Gene Therapy
- 1 March 2012
β-Globin locus control region (LCR) sequences have been widely used for the regulated expression of the human β-globin gene in therapeutic viral vectors. In this study, we compare the expression of… Expand
Activin-A in the regulation of immunity in health and disease.
- I. Morianos, Gina Papadopoulou, M. Semitekolou, G. Xanthou
- Biology, Medicine
- Journal of autoimmunity
- 13 August 2019
The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a… Expand
Activin-A is overexpressed in severe asthma and is implicated in angiogenic processes
- K. Samitas, N. Poulos, +10 authors M. Gaga
- Medicine
- European Respiratory Journal
- 11 February 2016
Activin-A is a pleiotropic cytokine that regulates allergic inflammation. Its role in the regulation of angiogenesis, a key feature of airways remodelling in asthma, remains unexplored. Our objective… Expand
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways
- I. Morianos, A. Trochoutsou, +16 authors G. Xanthou
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 14 May 2020
Significance Pathogenic Th17 cells are critical drivers of autoimmune neuroinflammation in multiple sclerosis (MS). We report that administration of the cytokine activin-A ameliorated disease… Expand