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Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures.
The cytoprotective effect of three flavonoids, catechin, quercetin and diosmetin, was investigated on iron-loaded hepatocyte cultures, considering two parameters: the prevention of iron-increasedExpand
Free radical scavenging and antioxidant effects of lactate ion: an in vitro study.
Divergent literature data are found concerning the effect of lactate on free radical production during exercise. To clarify this point, we tested the pro- or antioxidant effect of lactate ion inExpand
Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.
We tested a new synthetic, 8-hydroxyquinoline-based, hexadentate iron chelator, O-Trensox and compared it with desferrioxamine B (DFO). Iron mobilisation was evaluated: (i) in vitro by using ferritinExpand
Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures.
Oxidative DNA damage and its repair in primary rat hepatocyte cultures was investigated following 4 h of incubation with the toxic iron chelate, ferric nitrilotriacetate (Fe-NTA), in the presence orExpand
Effect of nitric oxide on iron‐mediated oxidative stress in primary rat hepatocyte culture
An iron‐mediated oxidative stress caused by an increase of the intracellular pool of low molecular weight complex of iron (LMWC) can be observed with iron overloading or ethanol metabolism. The aimExpand
Iron-induced oxidative DNA damage and its repair in primary rat hepatocyte culture.
Iron-overload diseases frequently develop hepatocellular carcinoma. The genotoxic mechanism whereby iron is involved in hepatocarcinogenesis might involve an oxidative process via the intermediateExpand
A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
Obesity and nonalcoholic fatty liver disease (NAFLD) can increase susceptibility to hepatotoxicity induced by some xenobiotics including drugs, but the involved mechanisms are poorly understood. ForExpand
Role of flavonoids and iron chelation in antioxidant action.
Publisher Summary This chapter discusses the role of flavonoids and iron chelation in antioxidant action. The potential of flavonoids to inhibit lipid peroxidation in biological models is supposed toExpand
Mechanism of tert-butylhydroperoxide induced apoptosis in rat hepatocytes: involvement of mitochondria and endoplasmic reticulum.
The purpose of the present work was to study the mechanisms involved in apoptosis induced by oxidative stress in rat hepatocytes. We focused on the apoptotic signaling molecules cytochrome c, Bcl-2Expand
Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice
Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease. The pre-existence of fatExpand