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Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures.
Free radical scavenging and antioxidant effects of lactate ion: an in vitro study.
- C. Groussard, I. Morel, M. Chevanne, M. Monnier, J. Cillard, A. Delamarche
- Medicine, ChemistryJournal of applied physiology
- 1 July 2000
It is suggested that lactate ion may prevent lipid peroxidation by scavenging free radicals such as O(2)(-).
Effect of nitric oxide on iron‐mediated oxidative stress in primary rat hepatocyte culture
The results favor the conclusion that NO acts as an antioxidant in iron‐mediated oxidative stress in rat hepatocytes, and plays a critical role in protecting the liver from oxidative stress.
Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.
Iron-induced oxidative DNA damage and its repair in primary rat hepatocyte culture.
- V. Abaléa, J. Cillard, M. Dubos, J. Anger, P. Cillard, I. Morel
- Biology, ChemistryCarcinogenesis
- 1 June 1998
It is demonstrated that even though DNA repair pathways were activated in iron-loaded hepatocyte cultures, these processes were not stimulated enough to prevent an accumulation of highly mutagenic DNA oxidative products in genomic DNA.
Role of flavonoids and iron chelation in antioxidant action.
Kinetic evaluation of free malondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Involvement of free radicals.
Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures.
Mechanism of tert-butylhydroperoxide induced apoptosis in rat hepatocytes: involvement of mitochondria and endoplasmic reticulum.
Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice
- J. Aubert, K. Begriche, B. Fromenty
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 September 2012
Early APAP-induced hepatotoxicity was greater in db/db than ob/ob mice, despite less severe fatty liver and similar basal levels of transaminases, as assessed by plasma transaminase, liver histology, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay.