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Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR.
Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause of enhancedExpand
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Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients
The gut microbial association with host co-existence is critical for body homeostasis and pathogenicity. Graves' disease (GD) is an autoimmune disease manifested with hyperthyroidism andExpand
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Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice
Objective: This study aims to investigate the effect of astragaloside IV on adipose lipolysis and hepatic gluconeogenesis. Methods: High-fat diet (HFD) feeding induced adipose dysfunction withExpand
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Phytocosmeceutical formulation development, characterization and its in-vivo investigations.
Several plants found rich in flavonoid, polyphenols, and antioxidants reported antiaging, oppose inflammation and carcinogenic properties but have rarely been applied in dermatology. The presentExpand
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Moisturizing effect of stable cream containing Crocus sativus extracts.
The present study is about to prepare stable cream of water-in-oil emulsion containing extracts of Crocus sativus against its base (without extracts) taken as control, to determine its stability onExpand
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Significance of Prescription Elements and Reasons of Prescription Errors in South Punjab, Pakistan
Background: Prescription is a paper or electronic document issued by licensed medical practitioner detailing the medicine or medicines to be dispensed for an individually named patient. The objectiveExpand
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A Smart Paclitaxel-Disulfiram Nanococrystals for Efficient MDR Reversal and Enhanced Apoptosis
PurposeA multidrug resistance (MDR) modulator, disulfiram (DSF), was incorporated into pure paclitaxel (PTX) nanoparticles to construct a smart paclitaxel-disulfiram nanococrystals (PTX-DSF Ns)Expand
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Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients.
The gut microbiota has a crucial effect on human health and physiology. Hypothyroid Hashimoto's thyroiditis (HT) is an autoimmune disorder manifested with environmental and genetic factors. However,Expand
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A novel ventricular restraint device (ASD) repetitively deliver Salvia miltiorrhiza to epicardium have good curative effects in heart failure management.
A novel ventricular restraint is the non-transplant surgical option for the management of an end-stage dilated heart failure (HF). To expand the therapeutic techniques we design a novel ventricularExpand
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Drug nanocrystals: Fabrication methods and promising therapeutic applications.
The drug nanocrystals (NCs) with unique physicochemical properties are now considered as a promising drug delivery system for poorly water-soluble drugs. So far >20 formulations of NCs have beenExpand
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