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P-type calcium channels blocked by the spider toxin ω-Aga-IVA
TLDR
A peptide toxin from funnel web spider venom, ω-Aga-IVA, is identified, which is a potent inhibitor of both calcium entry into rat brain synaptosomes and of 'P-type' calcium channels8 in rat Purkinje neurons, which will facilitate characterization of brain calcium channels resistant to existing channel blockers and may assist in the design of neuroprotective drugs.
Response properties of motoneurones in a slice preparation of the turtle spinal cord.
TLDR
The experiments confirm and extend the identification of the ionic conductances underlying the active response properties of spinal motoneurones, which are closely similar to those known from mammals in vivo.
Calcium conductance and firing properties of spinal motoneurones in the turtle.
TLDR
It is concluded that the transient and the sustained Ca2+ fluxes in spinal motoneurones are curtailed by different K+ conductances.
Plateau potentials in alpha‐motoneurones induced by intravenous injection of L‐dopa and clonidine in the spinal cat.
TLDR
It is concluded that L‐DOPA (and clonidine) change the response properties of the motoneurones in an analogous way to 5‐hydroxy‐DL‐tryptophan (5‐HTP).
Dendrodendritic Inhibition Through Reversal of Dopamine Transport
TLDR
These findings demonstrate that dendrodendritic autoinhibition entails the carrier-mediated release of dopamine rather than conventional exocytosis, and suggests that some widely used antidepressants that inhibit the dopamine transporter may benefit patients in the early stages of Parkinson's disease.
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