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Responsiveness to 6-n-Propylthiouracil (PROP) Is Associated with Salivary Levels of Two Specific Basic Proline-Rich Proteins in Humans
The findings suggest that PRB1, in addition to TAS2R38 and gustin, could contribute to individual differences in thiourea sensitivity, and the expression of the PROP phenotype as a complex genetic trait. Expand
Blood bank conditions and RBCs: the progressive loss of metabolic modulation
The effect of storage on this metabolic modulation and its relationship with the alteration of membrane protein composition in human RBC is investigated. Expand
The multiple functions of hemoglobin.
Several parallel biological functions of hemoglobin besides its basic function of oxygen transport are discussed and hemoglobin as source of physiological active catabolites is discussed. Expand
Facts and artifacts in proteomics of body fluids. What proteomics of saliva is telling us?
Several technological and analytical problems and pitfalls that had to be surmounted during studies focussed on the extensive qualitative and quantitative characterization of salivary peptidoma and mainly based on LC-MS analyses of intact naturally occurring peptides are described. Expand
Trafficking and Postsecretory Events Responsible for the Formation of Secreted Human Salivary Peptides
To elucidate the localization of post-translational modifications of different classes of human salivary proteins and peptides (acidic and basic proline-rich proteins (PRPs), Histatins, Statherin,Expand
Characterization of the human salivary basic proline-rich protein complex by a proteomic approach.
A correlation matrix analysis revealed a cluster of correlation among all the basic PRPs (apart from the P-B peptide) which is in agreement with their common parotid origin. Expand
Saliva and the Control of Its Secretion
The various functions of saliva—among them digestive, protective and trophic ones—not just limited to the mouth, and the relative contribution of the different types of gland to the total volumeExpand
Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes
The study revealed that statherin, proline-rich peptide P-B, P-C peptide, and histatins, were significantly less concentrated in saliva of diabetic subjects than in controls, while concentration of α-defensins 1, 2 and 4 and S100A9* was higher. Expand
Proton nuclear magnetic resonance spectral profiles of urine in type II diabetic patients.
Although lactate, citrate, alanine, and hippurate concentrations increased with increasing glycosuria and glycohemoglobin, trimethylamine-N-oxide and dimethylamines were present at high concentrations even in diabetics with good metabolic control. Expand
Human erythrocyte metabolism is modulated by the O2‐linked transition of hemoglobin
The hypothesis of a modulation of the relative rates of PPP and glycolysis achieved through competition between deoxy‐hemoglobin (deoxy‐Hb) and Glycolytic enzymes for the cytoplasmic domain of band 3 is supported. Expand