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The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins
The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to theseExpand
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A visual motion detection circuit suggested by Drosophila connectomics
Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. ForExpand
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Axonal Transport of Mitochondria to Synapses Depends on Milton, a Novel Drosophila Protein
A protein required to localize mitochondria to Drosophila nerve terminals has been identified genetically. Photoreceptors mutant for milton show aberrant synaptic transmission despite normalExpand
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Synaptic organization of columnar elements in the lamina of the wild type in Drosophila melanogaster
The synaptic connections within the lamina, the first of the optic neuropiles underlying the insect's compound eye, have been little studied in Drosophila melanogaster until now, despite the geneticExpand
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The Neural Substrate of Spectral Preference in Drosophila
Drosophila vision is mediated by inputs from three types of photoreceptor neurons; R1-R6 mediate achromatic motion detection, while R7 and R8 constitute two chromatic channels. Neural circuits forExpand
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Endophilin Mutations Block Clathrin-Mediated Endocytosis but Not Neurotransmitter Release
We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramaticallyExpand
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Synaptic organization of the mushroom body calyx in Drosophila melanogaster
The calyx neuropil of the mushroom body in adult Drosophila melanogaster contains three major neuronal elements: extrinsic projection neurons, presumed cholinergic, immunoreactive to cholineExpand
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A Slowed Classical Pathway Rather Than Kiss-and-Run Mediates Endocytosis at Synapses Lacking Synaptojanin and Endophilin
The extent to which a "kiss-and-run" mode of endocytosis contributes to synaptic-vesicle recycling remains controversial. The only genetic evidence for kiss-and-run at the synapse comes fromExpand
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The functional organisation of glia in the adult brain of Drosophila and other insects
This review annotates and categorises the glia of adult Drosophila and other model insects and analyses the developmental origins of these in the Drosophila optic lobe. The functions of glia in theExpand
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The protocadherin Flamingo is required for axon target selection in the Drosophila visual system
Photoreceptor neurons (R cells) in the Drosophila visual system elaborate a precise map of visual space in the brain. The eye contains some 750 identical modules called ommatidia, each containingExpand
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