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Emendation of the genus Sphingomonas Yabuuchi et al. 1990 and junior objective synonymy of the species of three genera, Sphingobium, Novosphingobium and Sphingopyxis, in conjunction with Blastomonas
TLDR
None of the physiological and biochemical characteristics considered, including cellular lipids and fatty acid composition, provided evidence for the division of the current genus Sphingomonas, and it is concluded that the genus should remain undivided at this time. Expand
A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis.
TLDR
By rapidly regenerating lipidomic datasets during biological processes, comparative lipidomics provides statistically valid, organism-wide comparisons that broadly assess lipid changes during infection or among clinical strains of mycobacteria. Expand
Mycobacterium tuberculosis Regulates CD1 Antigen Presentation Pathways through TLR-21
TLDR
Mycobacterial cell wall lipids provide two distinct signals for the activation of lipid-reactive T cells: lipid Ags that activate T cell receptors and lipid adjuvants that activate APCs through TLR-2, which may represent a system for selectively promoting the presentation of exogenous foreign lipids by those myeloid APCs which come into direct contact with pathogens. Expand
Characterization of the ybdT gene product of Bacillus subtilis: Novel fatty acid β-hydroxylating cytochrome P450
TLDR
Results suggest that this P450 enzyme is involved in a novel biosynthesis of β-hydroxy fatty acid in Sphingomonas paucimobilis. Expand
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
TLDR
This strategy identified a previously unknown, Mycobacterium tuberculosis-specific lipid, 1-tuberculosinyladenosine, which is produced by the Rv3378c enzyme, and establishes its role as a tuberculo-prenyl transferase and suggests a revised biosynthetic pathway for the sequential action of Rv 3377c-Rv 3378c. Expand
Substrate Recognition and Molecular Mechanism of Fatty Acid Hydroxylation by Cytochrome P450 from Bacillus subtilis
TLDR
A possible mechanism for the hydroxylation reaction catalyzed by P450BSβ is proposed in which the carboxylate of the bound-substrate fatty acid assists in the cleavage of the peroxide O-O bond. Expand
Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells
TLDR
These studies establish the genetic and enzymatic basis for a previously unknown type of polyketide, designated mycoketide, which contains a lipidic pathogen-associated molecular pattern. Expand
Mincle is a long sought receptor for mycobacterial cord factor
TLDR
The identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design. Expand
CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs.
TLDR
T cell responses were strongest for synthetic compounds that mimicked the natural branched lipids produced by mycobacterial polyketide synthase 12, which may represent a new lipid-based pathogen-associated molecular pattern. Expand
Functional modulation of a peroxygenase cytochrome P450: novel insight into the mechanisms of peroxygenase and peroxidase enzymes
TLDR
Results suggest that there are critical structural elements at the distal active site which determine whether this enzyme acts as a peroxygenase or a peroxidase. Expand
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