• Publications
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Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications
High-throughput DNA sequencing technology has transformed genetic research and is starting to make an impact on clinical practice. However, analyzing high-throughput sequencing data remainsExpand
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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are notExpand
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Genome-wide patterns of selection in 230 ancient Eurasians
Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selectionExpand
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The genetic history of Ice Age Europe
Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. We analyze genome-wide data from 51 Eurasians fromExpand
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Differential confounding of rare and common variants in spatially structured populations
Well-powered genome-wide association studies, now made possible through advances in technology and large-scale collaborative projects, promise to characterize the contribution of rare variants toExpand
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Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS inExpand
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Strong male bias drives germline mutation in chimpanzees
Male chimps evolve faster with age Chimpanzees are evolving faster than humans. Venn et al. examined the genetics of three generations of western chimpanzees and found that overall the mutation rateExpand
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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations withExpand
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Estimating Selection Coefficients in Spatially Structured Populations from Time Series Data of Allele Frequencies
Inferring the nature and magnitude of selection is an important problem in many biological contexts. Typically when estimating a selection coefficient for an allele, it is assumed that samples areExpand
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Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
Genetic predictions of height differ among human populations and these differences have been interpreted as evidence of polygenic adaptation. These differences were first detected using SNPsExpand
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