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Splenic trauma: WSES classification and guidelines for adult and pediatric patients
TLDR
The World Society of Emergency Surgery (WSES) classification of splenic trauma and the management guidelines are presented to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management.
Prehospital ultrasound imaging improves management of abdominal trauma
TLDR
The purpose of this prospective, multicentre study was to compare the accuracy of physical examination and prehospital focused abdominal sonography for trauma (PFAST) to detect abdominal bleeding.
SERUM S-100B CONCENTRATION PROVIDES ADDITIONAL INFORMATION FOT THE INDICATION OF COMPUTED TOMOGRAPHY IN PATIENTS AFTER MINOR HEAD INJURY: A PROSPECTIVE MULTICENTER STUDY
TLDR
It is investigated whether S-100B concentrations in patients with MHI can provide additional information to improve indication of the need for an initial CCT scan and whether adding the measurement of S- 100B concentration to the clinical decision rules for a C CT scan in patientswith MHI could allow a 30% reduction in scans.
Differential release of interleukines 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury.
TLDR
Analysis of IL-6, IL-8, and IL-10 in cerebrospinal fluid and in plasma with respect to blood-brain barrier (BBB) integrity in 29 patients suffering from isolated TBI found alterations of the BBB seems not to influence the distribution pattern of interleukines in CSF and plasma after trauma.
WSES guidelines on acute calculous cholecystitis Ansaloni , L . 2016-06-14
TLDR
The algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality.
EARLY VERSUS LATE ONSET OF MULTIPLE ORGAN FAILURE IS ASSOCIATED WITH DIFFERING PATTERNS OF PLASMA CYTOKINE BIOMARKER EXPRESSION AND OUTCOME AFTER SEVERE TRAUMA
TLDR
It is demonstrated that mortality differs significantly between the development of EMOF and LMOF after traumatic injury and the predictive value of cytokine biomarkers of MOF and lethal outcome and suggested that serum cytokine measurements may be important early biochemical markers for predicting thedevelopment of delayed MOF.
Establishment and characterization of the Masquelet induced membrane technique in a rat femur critical‐sized defect model
TLDR
It was concluded that cellular composition and growth factor content in induced membranes depends on the location where the membrane is induced and differs from periosteum.
The definition of polytrauma revisited: An international consensus process and proposal of the new ‘Berlin definition’
TLDR
Based on several consensus meetings and a database analysis, a panel of international experts proposes the following parameters for a definition of “polytrauma”: significant injuries of three or more points in two or more different anatomic AIS regions in conjunction with one or more additional variables from the five physiologic parameters.
Endothelial progenitor cells and mesenchymal stem cells seeded onto beta-TCP granules enhance early vascularization and bone healing in a critical-sized bone defect in rats.
TLDR
This cell approach suggests that there is a synergistic effect and that the initial stage of neovascularization by EPCs is considered to be crucial for complete bone regeneration in the late phase.
Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells.
TLDR
The results suggest that simvastatin induces apoptosis in tumor cells and its anti-proliferative activity was accompanied by inhibition of cyclin-dependent kinases and cyclins, whereas CDK inhibitors p19 and p27 were enhanced.
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