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A Randomized Controlled Trial of Exercise and Manipulative Therapy for Cervicogenic Headache
Study Design. A multicenter, randomized controlled trial with unblinded treatment and blinded outcome assessment was conducted. The treatment period was 6 weeks with follow-up assessment afterExpand
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Guidelines for the design of clinical trials with longitudinal outcomes.
A common objective of longitudinal clinical trials is to compare rates of change in a continuous response variable between two groups. Expand
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Exertional oxygen of limited benefit in patients with chronic obstructive pulmonary disease and mild hypoxemia.
It is unclear whether short-term benefits from supplemental oxygen translate into improved quality of life in patients with severe COPD. In a 12 wk double-blind randomized crossover study, weExpand
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A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer.
BACKGROUND In the setting of metastatic colorectal cancer (CRC), anti-EGFR antibodies are not currently recommended for individuals with KRAS mutant tumours. This is based on subgroup analyses ofExpand
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Interim analysis of continuous long-term endpoints in clinical trials with longitudinal outcomes.
This paper discusses interim analysis for clinical trials where the primary endpoint is observed at a specific long-term follow-up time, but where repeated measures of the same outcome are also takenExpand
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glm2 : fitting generalized linear models with convergence problems
The R function glm uses step-halving to deal with certain types of convergence problems when using iteratively reweighted least squares to fit a generalized linear model. Expand
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Baseline Predictors of CD4 T‐Lymphocyte Recovery With Combination Antiretroviral Therapy
&NA; CD4 T‐cell recovery with potent antiretroviral therapy varies considerably among HIV‐1‐infected patients. Data from two studies that enrolled subjects at different stages of disease progressionExpand
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The effect of heterogeneity on the spread of disease
In the formulations of standard epidemic models it is usually assumed that, as far as the spread of the disease is concerned, the community consists of homogeneous individuals who mix uniformly withExpand
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Regional differences in multinational clinical trials: anticipating chance variation
Background Multinational clinical trials efficiently pool resources and provide treatment comparisons across diverse populations. However, they may be difficult to interpret when there are largerExpand
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Gefitinib or Erlotinib vs Chemotherapy for EGFR Mutation-Positive Lung Cancer: Individual Patient Data Meta-Analysis of Overall Survival
Background We performed an individual patient data meta-analysis to examine the impact of first-generation epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitor (TKI) therapy on overallExpand
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