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Nanotubular Highways for Intercellular Organelle Transport
TLDR
Highly sensitive nanotubular structures formed de novo between cells that create complex networks facilitate the selective transfer of membrane vesicles and organelles but seem to impede the flow of small molecules are described. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
The Utility of Human Epididymal Protein 4, Cancer Antigen 125, and Risk for Malignancy Algorithm in Ovarian Cancer and Endometriosis
TLDR
HE4 showed satisfactory capability of distinguishing endometriosis from ovarian cancer, which CA125 lacked, and the Risk of Ovarian Malignancy Algorithm score proved to be useful in excluding malignant diagnosis in premenopausal women. Expand
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
TLDR
AMPK-dependent protection from extracellular ASYN was also observed in rat neuron-like pheochromocytoma cell line PC12, suggesting that modulation of AMPK activity may be a promising therapeutic strategy in Parkinson's disease. Expand
Induced Resistance in the Human Non Small Cell Lung Carcinoma (NCI-H460) Cell Line In Vitro by Anticancer Drugs
TLDR
Gene expression data confirmed the induction of mdr1 (P-gp), as judged by the observed 15-fold increase in its mRNA concentration in doxorubicin-resistant NCI-H460/R cells, which should develop a rationale for a novel treatment of NSCLC with appropriate modulators of resistance aimed at improving the outcome of the acquired drug resistance. Expand
Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R)
TLDR
The results show that sulfinosine and curcumin overcome MDR in non-small cell lung carcinoma cell line (NSCLC), especially in combination despite the presence of a mutated p53 gene. Expand
Multiple mechanisms underlying the anticancer action of nanocrystalline fullerene.
TLDR
The multiple mechanisms underlying the in vitro anticancer effects of the C(60) fullerene water suspension are demonstrated and primary rat astrocytes were less sensitive than their transformed counterparts to a cytostatic action of low-dose nC(60). Expand
Anti-inflammatory, gastroprotective, and cytotoxic effects of Sideritis scardica extracts.
TLDR
It seems that phenolic compounds (apigenin, luteolin, and their corresponding glycosides) are responsible for the diethyl ether extract cytotoxic effect, and induction of oxidative stress might be involved in its cytotoxicity. Expand
Inhibition of mTOR-Dependent Autophagy Sensitizes Leukemic Cells to Cytarabine-Induced Apoptotic Death
TLDR
The data suggest that the therapeutic efficiency of cytarabine in leukemic patients could be increased by the inhibition of the mTOR-dependent autophagic response. Expand
Cyclohexyl analogues of ethylenediamine dipropanoic acid induce caspase-independent mitochondrial apoptosis in human leukemic cells.
TLDR
The cytotoxic effect in HL-60 cells was associated with an increase in superoxide production and mitochondrial membrane depolarization, leading to apoptotic cell death characterized by phosphatidylserine externalization and DNA fragmentation in the absence of autophagic response. Expand
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