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Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype
It is hypothesized that, in addition to the M1 and M2 phenotypes, an M3 switch phenotype exists that responds to proinflammatory stimuli with reprogramming towards the anti-inflammatory M2 phenotype, and signs of such a switch phenotype in lung diseases are found.
Nitric oxide is involved in heat‐induced HSP70 accumulation
Macrophages Reprogrammed In Vitro Towards the M1 Phenotype and Activated with LPS Extend Lifespan of Mice with Ehrlich Ascites Carcinoma
- S. Kalish, S. Lyamina, E. A. Usanova, E. Manukhina, N. P. Larionov, I. Malyshev
- Biology, MedicineMedical science monitor basic research
- 16 October 2015
Findings suggest that promising biotechnologies for restriction of tumor growth could be developed based on the in vitro macrophage reprogramming in Ehrlich ascites carcinoma.
Controlled modulation of inflammatory, stress and apoptotic responses in macrophages.
Complete analysis of, and appreciation for, the immunoregulatory mechanisms implicated in LPS-dependent reprogramming of immune responses in macrophages can be expected to increase the understanding of the host innate response, as well as allow investigators to utilize emerging immunologic technologies in effective treatment of infections and chronic inflammatory diseases.
Immunity, Tumors and Aging: The Role of HSP70
- I. Malyshev
- MedicineSpringerBriefs in Biochemistry and Molecular…
- 8 January 2013
That's it, a book to wait for in this month, immunity tumors and aging the role of hsp70; you may not be able to get in some stress, so don't go around and seek fro the book until you really get it.
Stress, adaptation, and nitric oxide.
This review substantiates the idea that the system of NO generation is a newly discovered stress-limiting system and demonstrates that pharmacological "imitation" of the activated NO-ergic system by administration of NO donors to the organism provides an efficient protection against stress damage and enhances the adaptive capacity of the organism.
NO-dependent mechanisms of adaptation to hypoxia.
No and the NO-dependent activation of HSP70 synthesis play important roles in adaptation to hypoxia.
Prevention of Neurodegenerative Damage to the Brain in Rats in Experimental Alzheimer’s Disease by Adaptation to Hypoxia
- E. Manukhina, A. Goryacheva, I. Malyshev
- Biology, PsychologyNeuroscience and Behavioral Physiology
- 16 July 2010
Adaptation to periodic hypoxia effectively prevented oxidative and nitrosative stress, protecting against neurodegenerative changes and protecting cognitive functions in experimental Alzheimer’s disease.
Protective Effects of Adaptation to Hypoxia in Experimental Alzheimer’s Disease
- E. Manukhina, A. Goryacheva, Pshennikova Mg, I. Malyshev, R. Mallet, H. Downey
- Biology, Psychology
Protective effects of adaptation to intermittent hypobaric hypoxia on the memory, brain neurons, and cerebral blood vessels in rats with experimental AD induced by intracerebral injections of beta-amyloid (Aβ) and mechanisms of these protective effects are focused on.
The Functions of HSP70 in Normal Cells
- I. Malyshev
The HSP70 ATPase cycle forms a protein quality control system or the FOlding Refolding Degradation machinery (FORD) and, depending on the state of the protein, sends the protein either for re-folding or for degradation.