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Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
TLDR
The main risk factors for reported episodes of severe and disabling LBP in UK women include the degree of LDD as assessed by MRI, being overweight and genetic heritability. Expand
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
TLDR
A meta-analysis of genome-wide association studies for whole body lean body mass and five novel genetic loci to be significantly associated is performed and provides new insight into the genetics ofLean body mass. Expand
Family-based study of association between ENPP1 genetic variants and craniofacial morphology
TLDR
The findings obtained in this study suggest that the upstream, promoter and 3′ untranslated regions in the ENPP1 locus harbor genetic variants affecting different aspects of craniofacial morphology. Expand
Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population
TLDR
Testing the hypothesis that genetic variation at the ENPP1 locus is involved in the etiology of osteoarthritis of the hand revealed a substantial contribution of genetic factors to the overall trait variance in this homogeneous population of nuclear families. Expand
Assessment of age-related changes in heritability and IGF-1 gene effect on circulating IGF-1 levels
TLDR
This is the first study to test the age × genotype interaction in IGF-1 levels and the genomic region marked by rs855203 may consequently be of significance for further molecular and pharmacogenetic research, in particular in advanced age. Expand
The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample
TLDR
In conclusion, in addition to the association of CNR2 polymorphisms with low BMD at selected clinically relevant skeletal sites, their significant association with hand bone strength phenotypes is reported using a family-based study design implying an even broader impact of genetic variation at the C NR2 locus on bone structure and function. Expand
Hand bone midshaft enthesophytes: the influence of age, sex, and heritability.
TLDR
Evaluated enthesophytes and osteophytes are manifestations of different etiological processes and the contribution of the genetic and common environmental factors to ES and OS variations is compared. Expand
Longitudinal study of variation in body mass index in middle-aged UK females
TLDR
The data suggest that individual age-related changes in BMI are very different, and simply combining all individuals into groups by any other criteria and overlooking the distinctive patterns of BMI change may lead to biased inferences in epidemiologic and etiologic research of the future. Expand
Low Back and Common Widespread Pain Share Common Genetic Determinants
TLDR
Implementing Falconer's polygenic threshold concept for dichotomous traits inheritance, new software was developed to examine the extent of the genetic influence on LBP and CWP under age and BMI dependence and found contribution of BMI to variation/covariation of both pain phenotypes was not determinative. Expand
Modelling of age-related bone loss using cross-sectional data
TLDR
The change of phalangeal BMD with age may be best described by a two-interval function, regardless of sex and ethnic background, however, specific parameter estimates depend both on gender and ethnic affiliation. Expand
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