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Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.
  • I. Lucki
  • Psychology, Biology
    Behavioural pharmacology
  • 1 November 1997
The revised scoring of the forced swimming test corresponds to a behavioral test for antidepressant drugs that meet these criteria and should be sensitive to all antidepressant drugs and should also display multiple components that are sensitive to specific drug classes.
Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice
Abstract.Rationale: Recent advances in neurobehavioral genetics have increased the importance of research on the behavioral patterns of different mouse strains. A comprehensive comparison of inbred
The spectrum of behaviors influenced by serotonin
  • I. Lucki
  • Psychology, Biology
    Biological Psychiatry
  • 1 August 1998
Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment
The effects of antidepressants were augmented following chronic administration for 14 days, especially when given at low doses, suggesting that modifications of the FST can be used to examine the onset of action of antidepressant agents produced by long-term administration.
Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors.
  • J. Cryan, I. Lucki
  • Biology, Psychology
    The Journal of pharmacology and experimental…
  • 1 December 2000
The results strongly implicate a role for 5-HT(2C) receptors in the behavioral effects of antidepressant drugs and exemplify the benefits of using the modified rat forced swim test, which was sensitive to serotonergic compounds and distinguished behavioral changes associated with serotoneric and noradrenergic effects.