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Wnt/β‐Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells
Embryonic stem cells (ESCs) represent not only a promising source of cells for cell replacement therapy, but also a tool to study the molecular mechanisms underlying cellular signaling andExpand
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Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.
Control over progenitor proliferation and neurogenesis remains a key challenge for stem cell neurobiology and a prerequisite for successful stem cell replacement therapies for neurodegenerativeExpand
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The Generation of Dopaminergic Neurons by Human Neural Stem Cells Is Enhanced by Bcl-XL, Both In Vitro and In Vivo
Progress in stem cell biology research is enhancing our ability to generate specific neuron types for basic and applied studies and to design new treatments for neurodegenerative diseases. In theExpand
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Neural progenitors organize in small-world networks to promote cell proliferation
Significance Synchronized activity among groups of interconnected cells is essential for diverse functions in the brain. Most studies on neuronal networks have been performed in the mature brain whenExpand
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Generation and properties of a new human ventral mesencephalic neural stem cell line.
Neural stem cells (NSCs) are powerful research tools for the design and discovery of new approaches to cell therapy in neurodegenerative diseases like Parkinson's disease. Several epigenetic andExpand
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DNGR‐1+ dendritic cells are located in meningeal membrane and choroid plexus of the noninjured brain
The role and different origin of brain myeloid cells in the brain is central to understanding how the central nervous system (CNS) responds to injury. C‐type lectin receptor family 9, member AExpand
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Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells
Amyloid precursor protein (APP) is a member of the APP family of proteins, and different enzymatic processing leads to the production of several derivatives that are shown to have distinct biologicalExpand
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Recent progress and challenges for the use of stem cell derivatives in neuron replacement therapy for Parkinson’s disease
Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons of the sub-stantia nigra pars compacta (SNpc). Although dopamine (DA) loss is not the only important factor in theExpand
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Stem Cells as In Vitro Model of Parkinson's Disease
Progress in understanding neurodegenerative cell biology in Parkinson's disease (PD) has been hampered by a lack of predictive and relevant cellular models. In addition, the lack of an adequate inExpand
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Current advances in the generation of human iPS cells: implications in cell‐based regenerative medicine
Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human somatic cells has proved to be one of the most potentially useful discoveries in regenerative medicine.Expand
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