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Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin.Expand
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Intraneuronal trafficking of G-protein-coupled receptors in vivo
In vitro studies have widely demonstrated that the abundance and availability of G-protein-coupled receptors (GPCRs) at the cell surface is regulated by the neuronal environment and is the result ofExpand
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Progress in Stem Cell Therapy for Major Human Neurological Disorders
Human neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease, stroke or spinal cord injury are caused by the loss of neurons and glial cells in the brain or spinal cord in theExpand
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Ca2+ and cAMP signaling in human embryonic stem cell-derived dopamine neurons.
Human embryonic stem (hES) cell differentiation into dopamine neurons is considered a promising strategy for cell replacement therapy in Parkinson's disease, yet the functional properties of hESExpand
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Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice
We have studied the consequences of the constitutive acetylcholinesterase (AChE) deficiency in knockout mice for the AChE gene on the subcellular localization of the m2 receptor (m2R) and theExpand
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Bcl-XL modulates the differentiation of immortalized human neural stem cells
Understanding basic processes of human neural stem cell (hNSC) biology and differentiation is crucial for the development of cell replacement therapies. Bcl-XL has been reported to enhanceExpand
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Acute and Chronic Acetylcholinesterase Inhibition Regulates in Vivo the Localization and Abundance of Muscarinic Receptors m2 and m4 at the Cell Surface and in the Cytoplasm of Striatal Neurons
Acetylcholinesterase inhibitors (AChE-I) of various pharmacological classes have been used to provoke acute and chronic hypercholinergy in brain. Each condition induces a dramatic decrease of theExpand
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In Vitro and in Vivo Enhanced Generation of Human A9 Dopamine Neurons from Neural Stem Cells by Bcl-XL*
Human neural stem cells derived from the ventral mesencephalon (VM) are powerful research tools and candidates for cell therapies in Parkinson disease. Previous studies with VM dopaminergic neuronExpand
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Modulation of the generation of dopaminergic neurons from human neural stem cells by Bcl-X(L): mechanisms of action.
Understanding the developmental mechanisms governing dopaminergic neuron generation and maintenance is crucial for the development of neuronal replacement therapeutic procedures, like in Parkinson'sExpand
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