I. Legakis

Publications35
h-index15
Citations451
Highly Influential Citations24
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Positive correlation of galanin with glucose in type 2 diabetes.
Compelling literature (1) has been accumulated regarding the action of galanin as an incretin on insulin secretion. Although galanin inhibits glucose-stimulated insulin release in animals, no such… Expand
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Positive correlation of galanin with glucose in healthy volunteers during an oral glucose tolerance test.
Galanin has been found in increased amounts in subjects with type 2 diabetes. The purpose of the present study was to determine the levels of galanin in healthy volunteers during an oral glucose… Expand
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Recent Advances in Molecular Diagnosis of Thyroid Cancer
Recent molecular studies have described a number of abnormalities associated with the progression and dedifferentiation of thyroid carcinoma. These distinct molecular events are often associated with… Expand
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Serum Total Antioxidant Status in Severe Exacerbation of Asthma: Correlation with the Severity of the Disease
Oxidative processes, mediated by oxygen free radicals are recognized to contribute significantly to the inflammatory pathology of bronchial asthma. An imbalance between oxidants and antioxidants has… Expand
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Active Contours Guided by Echogenicity and Texture for Delineation of Thyroid Nodules in Ultrasound Images
TLDR
This paper presents a novel active contour model for precise delineation of thyroid nodules of various shapes according to their echogenicity and texture, as displayed in ultrasound (US) images. Expand
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Dissociation of ACTH, beta-endorphin and cortisol in graded sepsis.
The function of the hypothalamic-pituitary-adrenal axis as related to the degree of severity of a septic process was assessed by measuring plasma levels of beta-endorphin, ACTH and cortisol.… Expand
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The role of galanin in metabolic disorders leading to type 2 diabetes mellitus.
  • I. Legakis
  • Biology, Medicine
  • Drug news & perspectives
  • 1 April 2005
A large number of neurotransmitters have been identified that influence food intake when administered directly into the central nervous system of experimental animals. In some cases, there is… Expand
  • 28
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Decreased glucagon-like peptide 1 fasting levels in type 2 diabetes.
The significance of over- or underproduction of glucagon-like peptide 1 (GLP-1) (7–36) amide in diabetes remains controversial (1,2). Although it has been proposed that at least one factor… Expand
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Elevated prolactin to cortisol ratio and polyclonal autoimmune activation in Hashimoto's thyroiditis.
Cortisol and prolactin, which are considered to have an immunomodulatory effect, and selected autoantibodies were determined in Hashimoto's thyroiditis. 37 patients (8 males and 29 females) (54 +/-… Expand
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Thyroid function and prevalence of anti-thyroperoxidase (TPO) and anti-thyroglobulin (Tg) antibodies in outpatients hospital setting in an area with sufficient iodine intake: influences of age and…
In order to examine the prevalence of thyroid disease in a hospital outpatient setting, in an area of sufficient iodine intake, serum levels of TSH, T4, T3, anti-Tg and anti-TPO antibodies were… Expand
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