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Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
BACKGROUND Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2Expand
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Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Background— Higher levels of physical activity are associated with fewer cardiovascular disease (CVD) events. Although the precise mechanisms underlying this inverse association are unclear,Expand
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Long-Term Weight Loss and Changes in Blood Pressure: Results of the Trials of Hypertension Prevention, Phase II
Approximately one fourth of the U.S. adult populationnearly 50 million peoplehas hypertension (1, 2). Taking a broader perspective, more than half of the adult population has higher than optimalExpand
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Dose Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis
Background No reviews have quantified the specific amounts of physical activity required for lower risks of coronary heart disease when assessing the dose-response relation. Instead, previous reviewsExpand
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Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults.
IMPORTANCE Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE ToExpand
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Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship.
IMPORTANCE The 2008 Physical Activity Guidelines for Americans recommended a minimum of 75 vigorous-intensity or 150 moderate-intensity minutes per week (7.5 metabolic-equivalent hours per week) ofExpand
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A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.
BACKGROUND Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar dataExpand
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Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mortality: A Large Pooled Cohort Analysis
Analyzing data from over 650,000 individuals, Dr. Steven Moore and colleagues report that greater amounts of leisure-time physical activity were associated with higher life expectancy across a wideExpand
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