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Pyoverdine siderophores: from biogenesis to biosignificance.
TLDR
Pyoverdines are a group of structurally related siderophores produced by fluorescent Pseudomonas species and the extremely high sequence diversity of genes involved in pyoverdine synthesis and uptake indicate that py overdine production is subject to high evolutionary pressure. Expand
The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.
TLDR
Biophysical analysis revealed that 2-alkyl-3-hydroxy-4-quinolones form complexes with iron(III) at physiological pH, and a secondary function for PQS in iron entrapment to facilitate siderophore-mediated iron delivery is revealed. Expand
Iron transport and regulation, cell signalling and genomics: lessons from Escherichia coli and Pseudomonas
TLDR
Recent advances in understanding of PvdS and FecI, a distinct subfamily of ECF sigma factors involved in iron acquisition and hence named the iron‐starvation sigmas, are reviewed. Expand
Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa
TLDR
It is shown that in addition to its role as an iron-scavenger, the siderophore pyoverdine that is secreted by Pseudomonas aeruginosa regulates the production of at least three virulence factors, which are major contributors to the ability of this bacterium to cause disease. Expand
Siderophore‐mediated cell signalling in Pseudomonas aeruginosa: divergent pathways regulate virulence factor production and siderophore receptor synthesis
TLDR
This work shows that a second divergent branch of this signalling pathway regulates the production of the FpvA protein, the first example of a branched signalling system of this sort and the first examples of an antisigma factor protein (FpvR) that directly regulates the activities of two different ECF sigma factor proteins (PvdS and FpVI). Expand
Excision and transfer of the Mesorhizobium loti R7A symbiosis island requires an integrase IntS, a novel recombination directionality factor RdfS, and a putative relaxase RlxS
TLDR
It is shown that the ICEMlSymR7AintS gene, which encodes an integrase of the phage P4 family, is required for integration and excision of the island and the presence of a plasmid with cloned island traR traI2 genes resulted in excision in all cells regardless of culture density, indicating that excision may be similarly regulated. Expand
Exotoxin A production in Pseudomonas aeruginosa requires the iron‐regulated pvdS gene encoding an alternative sigma factor
TLDR
Evidence is presented that the iron control of ETA synthesis is mediated by a Fur‐regulated alternative sigma factor, PvdS, which had initially been identified as a positive activator for the production of the siderophore pyoverdin. Expand
Pseudomonas syringae pv. actinidiae from Recent Outbreaks of Kiwifruit Bacterial Canker Belong to Different Clones That Originated in China
TLDR
The analyses of the core genome SNPs and the ICEs support the hypothesis of an independent Chinese origin for both the Italian and the New Zealand outbreaks and suggest the Chilean strains also originate from China. Expand
Cloning and characterization of pvdS, a gene required for pyoverdine synthesis in Pseudomonas aeruginosa: PvdS is probably an alternative sigma factor.
TLDR
It is proposed that in iron-rich cells of P. aeruginosa, Fur binds to the pvdS promoter and prevents expression of the gene; under conditions of iron starvation, repression is relieved and PvdS is made, reprogramming the cells for pyoverdine synthesis. Expand
Cell-surface signaling in Pseudomonas: stress responses, iron transport, and pathogenicity.
TLDR
Control of the expression and activity of ECF sigma factors are central to gene regulation via CSS, and the variety of intrinsic and extrinsic factors influencing these processes will be discussed. Expand
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