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Functional Role of Potassium Channels in the Vasodilating Mechanism of Levosimendan in Porcine Isolated Coronary Artery
- J. Pataricza, I. Krassói, J. Höhn, A. Kun, J. G. Papp
- Cardiovascular Drugs and Therapy
- 1 March 2003
Levosimendan, a new type of inodilator drugs, is known to activate membrane adenosine 3′,5′-triphosphate-sensitive potassium (KATP) channels in some vascular smooth muscles and causes vasorelaxation.… Expand
Vasorelaxing effect of levosimendan against 5‐hydroxytryptamine‐induced contractions in isolated human conduit bypass grafts
- J. Pataricza, Jenö Szolnoky, +4 authors Julius Gy. Papp
- The Journal of pharmacy and pharmacology
- 1 August 2006
Levosimendan is a novel inodilator drug developed for the treatment of heart failure. The possible vasodilating property of the drug in human coronary artery bypass grafts was investigated. Isometric… Expand
Differential Electrophysiologic Effects of Chronically Administered Amiodarone on Canine Purkinje Fibers versus Ventricular Muscle
- J. Papp, M. Németh, I. Krassói, L. Mester, O. Hála, A. Varró
- Journal of cardiovascular pharmacology and…
- 1 October 1996
Background: Acute and chronic treatment with amiodarone has been reported to cause different electrocardiographic changes in patients. The cellular electrophysiologic effects of chronic… Expand
C-type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries.
INTRODUCTION In addition to nitric oxide (NO), it is thought that an endothelium-derived hyperpolarizing factor (EDHF) plays an important role in the relaxation of penile arteries. Recently, it has… Expand
Suppression of Erythromycin‐induced Early Afterdepolarizations and Torsade de Pointes Ventricular Tachycardia by Mexiletine
- T. Fazekas, I. Krassói, C. Lengyel, A. Varró, J. Papp
- Pacing and clinical electrophysiology : PACE
- 1 January 1998
Erythromycin is a selective IKr‐blocking, action potential duration (APD)‐prolonging drug, which may induce early afterdepolarizations (EADs) and torsade de pointes ventricular tachycardia. The… Expand
Delayed antiischemic effect of prostaglandin I2 and of a new stable prostaglandin I2 analogue, 7-oxo-prostacyclin-Na, in experimental model angina in dogs.
Therapeutic application of prostaglandin I2 (PGI2) is rendered difficult by its instability. The 7-oxo-derivative synthesized by Kovács et al.  proved to be stable in aqueous solution. Both drugs… Expand
Calcium-Dependent Vasorelaxant Capacity of Levosimendan in Porcine and Human Epicardial Coronary Artery Preparations
In their recent letter, Koppel et al.  demonstrated that levosimendan (LEVO), a calcium-sensitizer inodilator agent , exerts minimal effects on smooth muscle tone in circular strips of bovine… Expand
NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery.
- Z. Márton, J. Pataricza, I. Krassói, A. Varró, J. G. Papp
- Medicine, Biology
- Vascular pharmacology
- 1 October 2005
C-type natriuretic peptide (CNP), a local regulator of vascular tone and cell proliferation, is eliminated from the circulation via NPR-C receptors and neutral endopeptidase enzyme (NEP, EC.… Expand
Improvement by phosphoramidon of damaged endothelial function in porcine coronary artery.
- I. Krassói, J. Pataricza, L. Torday, A. Kun, J. Papp
- The Annals of thoracic surgery
- 1 September 2000
BACKGROUND The bradykinin (BK)-induced endothelium-dependent relaxation is impaired in the presence of elevated potassium concentration enhancing the vasospastic tendency of large coronary arteries.… Expand
Role of calcium-activated potassium channels in the regulation of basal and agonist-elevated tones in isolated conduit arteries. Short communication.
Functional role of calcium-activated potassium (KCa) channels on the basal and agonist-elevated arterial tones was investigated in isolated rabbit aorta, porcine and canine coronary arteries as well… Expand