• Publications
  • Influence
Functional Role of Potassium Channels in the Vasodilating Mechanism of Levosimendan in Porcine Isolated Coronary Artery
Levosimendan, a new type of inodilator drugs, is known to activate membrane adenosine 3′,5′-triphosphate-sensitive potassium (KATP) channels in some vascular smooth muscles and causes vasorelaxation.Expand
  • 91
  • 4
Vasorelaxing effect of levosimendan against 5‐hydroxytryptamine‐induced contractions in isolated human conduit bypass grafts
Levosimendan is a novel inodilator drug developed for the treatment of heart failure. The possible vasodilating property of the drug in human coronary artery bypass grafts was investigated. IsometricExpand
  • 10
  • 2
Differential Electrophysiologic Effects of Chronically Administered Amiodarone on Canine Purkinje Fibers versus Ventricular Muscle
Background: Acute and chronic treatment with amiodarone has been reported to cause different electrocardiographic changes in patients. The cellular electrophysiologic effects of chronicExpand
  • 33
  • 1
C-type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries.
INTRODUCTION In addition to nitric oxide (NO), it is thought that an endothelium-derived hyperpolarizing factor (EDHF) plays an important role in the relaxation of penile arteries. Recently, it hasExpand
  • 42
  • 1
Suppression of Erythromycin‐induced Early Afterdepolarizations and Torsade de Pointes Ventricular Tachycardia by Mexiletine
Erythromycin is a selective IKr‐blocking, action potential duration (APD)‐prolonging drug, which may induce early afterdepolarizations (EADs) and torsade de pointes ventricular tachycardia. TheExpand
  • 23
  • 1
Delayed antiischemic effect of prostaglandin I2 and of a new stable prostaglandin I2 analogue, 7-oxo-prostacyclin-Na, in experimental model angina in dogs.
Therapeutic application of prostaglandin I2 (PGI2) is rendered difficult by its instability. The 7-oxo-derivative synthesized by Kovács et al. [8] proved to be stable in aqueous solution. Both drugsExpand
  • 13
Calcium-Dependent Vasorelaxant Capacity of Levosimendan in Porcine and Human Epicardial Coronary Artery Preparations
In their recent letter, Koppel et al. [1] demonstrated that levosimendan (LEVO), a calcium-sensitizer inodilator agent [2], exerts minimal effects on smooth muscle tone in circular strips of bovineExpand
  • 16
NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery.
C-type natriuretic peptide (CNP), a local regulator of vascular tone and cell proliferation, is eliminated from the circulation via NPR-C receptors and neutral endopeptidase enzyme (NEP, EC.Expand
  • 16
Improvement by phosphoramidon of damaged endothelial function in porcine coronary artery.
BACKGROUND The bradykinin (BK)-induced endothelium-dependent relaxation is impaired in the presence of elevated potassium concentration enhancing the vasospastic tendency of large coronary arteries.Expand
  • 9
Role of calcium-activated potassium channels in the regulation of basal and agonist-elevated tones in isolated conduit arteries. Short communication.
Functional role of calcium-activated potassium (KCa) channels on the basal and agonist-elevated arterial tones was investigated in isolated rabbit aorta, porcine and canine coronary arteries as wellExpand
  • 4