I. Kozone

Publications47
h-index16
Citations918
Highly Influential Citations22
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Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.
TLDR
Production of metabolites in some transformants of the versatile host was higher than that of the original producers, and cryptic biosynthetic gene clusters in the original producer were also expressed in a versatile host.
Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
TLDR
Characterization of giant modular polyketide synthases (PKSs) responsible for the production of aminopolyol polyketides and phylogenetic analysis of highly homologous but functionally diverse domains from the giant PKSs demonstrated the evolutionary mechanism for structural diversification ofpolyketides.
Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products.
TLDR
This is the first comprehensive study detailing the isolation of actinobacteria from a marine sponge and novel secondary metabolites from these strains, and JBIR-34 and -35 were particularly interesting because of their unique chemical skeleton.
Novel thioviridamide derivative—JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis
Novel thioviridamide derivative—JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis
New acylated anthocyanins from purple yam and their antioxidant activity
TLDR
The pigments found in purple yams from the Philippines were isolated and evaluated in terms of antioxidant activity, finding four new acylated anthocyanins, alanins (1–4) were isolated from the MeOH extracts of purple yam, which were subsequently determined to be cyanidin and peonidin type compounds.
Novel β‐1,3‐, 1,6‐oligoglucan elicitor from Alternaria alternata 102 for defense responses in tobacco
TLDR
A novel elicitor that induces chitinases in tobacco BY‐2 cells was isolated from Alternaria alternata 102 and the activity of this β‐1,3‐, 1,6‐glucan elicitor was about 1000 times more potent than that of laminarin, which is a known elicitor of defense responses in tobacco.
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
TLDR
The authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones, based on nature's diversification of the domain and module organizations.
Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host
TLDR
Light is shed on the expansion of chemical diversity of natural peptide products for drug development by discovering the gene cluster responsible for telomestatin biosynthesis and achieving production of telomstatin by heterologous expression of this cluster in the engineered Streptomyces avermitilis SUKA strain.
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55
GRP78/Bip is a molecular chaperone in the endoplasmic reticulum (ER) induced by ER stress that promotes protein folding and has an important role as a survival factor in solid tumors by providing…
Isolation of New Hexapeptides-JBIR-39 and JBIR-40-from a Marine Sponge-Derived Streptomyces sp. Sp080513SC-24
TLDR
New two hexapeptides, JBIR-39 (1), and -40 (2), were isolated from the fermentation broth of Sp080513SC-24 and the structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses.
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