• Publications
  • Influence
Enumerating all connected maximal common subgraphs in two graphs
  • I. Koch
  • Mathematics, Computer Science
  • Theor. Comput. Sci.
  • 6 January 2001
TLDR
We propose a new method for finding all connected maximal common subgraphs in two graphs which is based on the transformation of the problem into the clique problem. Expand
  • 217
  • 17
  • PDF
Application of Petri net based analysis techniques to signal transduction pathways
TLDR
We apply Petri net theory to model and analyse signal transduction pathways first qualitatively before continuing with quantitative analyses. Expand
  • 195
  • 8
  • PDF
Exploring the pathway structure of metabolism: decomposition into subnetworks and application to Mycoplasma pneumoniae
TLDR
A decomposition algorithm for metabolic networks based on the local connectivity of metabolites is presented. Expand
  • 225
  • 8
ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer.
Epidermal growth factor receptor (EGFR) overexpression and activation are hallmarks of non-small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies are used, the prognosis of NSCLC remainsExpand
  • 80
  • 7
  • PDF
An Algorithm for Finding Maximal Common Subtopologies in a Set of Protein Structures
TLDR
A graph-theoretical algorithm that finds all common subtopologies in a set of protein structures by enumerating all maximal cliques in a graph. Expand
  • 138
  • 6
Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma.
Cyclooxygenases (COX), especially COX-2, are considered to be involved in carcinogenesis. Our study was initiated to test whether expression of COX isoforms (COX-1 and COX-2) is linked to expressionExpand
  • 102
  • 5
  • PDF
Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer
BackgroundPrevious studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technologicalExpand
  • 136
  • 5
  • PDF
Application of Petri net theory for modelling and validation of the sucrose breakdown pathway in the potato tuber
TLDR
We provide an approach for model validation of metabolic networks using Petri net theory, which we demonstrate for the sucrose breakdown pathway in the potato tuber. Expand
  • 147
  • 5
Petri net modelling of gene regulation of the Duchenne muscular dystrophy
TLDR
A new application of Petri net theory is presented to model gene regulatory processes of Duchenne muscular dystrophy, based on own experimental and literature data. Expand
  • 73
  • 5
  • PDF
Model Validation of Biological Pathways Using Petri Nets - Demonstrated for Apoptosis
TLDR
This paper demonstrates the first steps of a new integrating methodology to develop and analyse models of biological pathways in a systematic manner using well established Petri net technologies. Expand
  • 126
  • 5
  • PDF