I. Koch

Publications
Influence

Enumerating all connected maximal common subgraphs in two graphs

I. Koch
Mathematics, Computer Science
Theor. Comput. Sci.
6 January 2001

We propose a new method for finding all connected maximal common subgraphs in two graphs which is based on the transformation of the problem into the clique problem. Expand

Application of Petri net based analysis techniques to signal transduction pathways

Andrea Sackmann, M. Heiner, I. Koch
Computer Science, Medicine
BMC Bioinformatics
2 November 2006

We apply Petri net theory to model and analyse signal transduction pathways first qualitatively before continuing with quantitative analyses. Expand

Exploring the pathway structure of metabolism: decomposition into subnetworks and application to Mycoplasma pneumoniae

S. Schuster, T. Pfeiffer, F. Moldenhauer, I. Koch, T. Dandekar
Computer Science, Medicine
Bioinform.
1 February 2002

A decomposition algorithm for metabolic networks based on the local connectivity of metabolites is presented. Expand

ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer.

A. Baumgart, S. Seidl, +13 authors T. Dechow
Biology, Medicine
Cancer research
1 July 2010

Epidermal growth factor receptor (EGFR) overexpression and activation are hallmarks of non-small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies are used, the prognosis of NSCLC remains… Expand

An Algorithm for Finding Maximal Common Subtopologies in a Set of Protein Structures

I. Koch, Thomas Lengauer, E. Wanke
Mathematics, Medicine
J. Comput. Biol.
1996

A graph-theoretical algorithm that finds all common subtopologies in a set of protein structures by enumerating all maximal cliques in a graph. Expand

Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma.

B. V. von Rahden, H. Stein, +6 authors M. Sarbia
Medicine
Cancer research
15 June 2005

Cyclooxygenases (COX), especially COX-2, are considered to be involved in carcinogenesis. Our study was initiated to test whether expression of COX isoforms (COX-1 and COX-2) is linked to expression… Expand

Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

S. Müller, Susanne Raulefs, +16 authors C. Michalski
Biology, Medicine
Molecular Cancer
25 April 2015

BackgroundPrevious studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technological… Expand

Application of Petri net theory for modelling and validation of the sucrose breakdown pathway in the potato tuber

I. Koch, B. Junker, M. Heiner
Computer Science, Medicine
Bioinform.
1 April 2005

We provide an approach for model validation of metabolic networks using Petri net theory, which we demonstrate for the sucrose breakdown pathway in the potato tuber. Expand

Petri net modelling of gene regulation of the Duchenne muscular dystrophy

S. Grunwald, A. Speer, J. Ackermann, I. Koch
Biology, Medicine
Biosyst.
1 May 2008

A new application of Petri net theory is presented to model gene regulatory processes of Duchenne muscular dystrophy, based on own experimental and literature data. Expand

Model Validation of Biological Pathways Using Petri Nets - Demonstrated for Apoptosis

M. Heiner, I. Koch, Jürgen Will
Medicine, Computer Science
CMSB
24 February 2003

This paper demonstrates the first steps of a new integrating methodology to develop and analyse models of biological pathways in a systematic manner using well established Petri net technologies. Expand

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