• Publications
  • Influence
Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
TLDR
Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. Expand
Response expectancy as a determinant of experience and behavior.
Response expectancies, defined as ex- pectancies of the occurrence of nonvolitional responses, have generally been ignored in theories of learning. Research on placebos, hypnosis, and fear reductionExpand
An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
TLDR
The results show that although conditioning may be sufficient for placebo analgesia, it is likely to be mediated by expectancy and magnitudes of placebo effect are dependent on multiple factors, including conditioning, expectancy, and whether analgesia is assessed concurrently or retrospectively. Expand
The Emperor's New Drugs: Exploding the Antidepressant Myth
TLDR
The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus and offers a path society can follow so that the authors stop popping pills and start proper treatment for depression. Expand
Imaginative suggestibility and hypnotizability: an empirical analysis.
TLDR
Unexpectedly, hypnosis was found to decrease suggestibility for a substantial minority of participants and Experiential response to hypnotic suggestion was predicted only by nonhypnotic suggestibility. Expand
Classical conditioning and the placebo effect
TLDR
Although conditioning trials significantly enhanced placebo responding, this effect was eliminated by adding expectancies to the regression equation, indicating that the effect of pairing trials on placebo response was mediated completely by expectancy. Expand
Listening to Prozac but Hearing Placebo: A Meta-Analysis of Antidepressant Medication
TLDR
Examination of pre–post effect sizes among depressed individuals assigned to no-treatment or wait-list control groups suggest that approximately one quarter of the drug response is due to the administration of an active medication, one half is a placebo effect, and the remaining quarter isdue to other nonspecific factors. Expand
Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome
TLDR
Whether open-label placebo is superior to a no-treatment control with matched patient-provider interactions in the treatment of irritable bowel syndrome (IBS) is tested and placebos administered without deception may be an effective treatment for IBS. Expand
Catastrophizing, depression and expectancies for pain and emotional distress
TLDR
Catastrophizing, but not depression, was associated with a tendency to underestimate pain and emotional distress, and response expectancies partially mediated the relation between catastrophizing and pain experience. Expand
Brain Activity Associated with Expectancy-Enhanced Placebo Analgesia as Measured by Functional Magnetic Resonance Imaging
TLDR
It is found that after placebo acupuncture treatment, subjective pain rating reduction on the placebo-treated side was significantly greater than on the control side, suggesting that placebo analgesia may be configured through multiple brain pathways and mechanisms. Expand
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