• Publications
  • Influence
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.
TLDR
It is shown that assignment to a reaction mechanistic domain is a critical first step in a strategic approach to understanding, ultimately on a quantitative basis, how chemical properties influence the potency of skin sensitizing chemicals. Expand
Allergic Contact Dermatitis
TLDR
This article seeks to consider skin sensitization and ACD in holistic fashion, bridging experimental observations with clinical disease and basic mechanisms with practical toxicology. Expand
Natural killer cells.
  • I. Kimber
  • Biology, Medicine
  • Medical laboratory sciences
  • 1985
Compilation of Historical Local Lymph Node Data for Evaluation of Skin Sensitization Alternative Methods
TLDR
A database of robust in vivo data to calibrate, evaluate, and eventually validate new approaches for skin sensitization testing is provided, which represents both the chemical and biologic diversity that is known to exist for chemical allergens and non‐allergens. Expand
Assessment of the safety of foods derived from genetically modified (GM) crops.
TLDR
The combination of existing test methods provides a sound test-regime to assess the safety of GM crops and is suitable for current and future GM crops with more complex modifications. Expand
Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals.
TLDR
The local lymph node assay, when conducted according to published guidelines, provides a robust method for skin sensitization testing that not only provides reliable hazard identification information but also data necessary for effective risk assessment and risk management. Expand
Classification of contact allergens according to potency: proposals.
TLDR
It is concluded that although the LLNA is the method of choice for the determination of skin sensitisation potency for the purposes of categorisation, if data are already available from appropriate guinea pig tests then their judicious interpretation may provide information of value in determinations of potency and categorisation. Expand
Langerhans cells require signals from both tumour necrosis factor‐α and interleukin‐1β for migration
TLDR
It was found that like anti‐TNF‐α, anti‐IL‐1β administered systemically to mice (by intraperitoneal injection), prior to skin sensitization with the contact allergen oxazolone, resulted in a marked inhibition of DC accumulation in draining lymph nodes. Expand
A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses
TLDR
Using a variety of statistical approaches to derive EC3 values from LLNA dose–response data for 10 chemicals, it has been demonstrated that simple linear interpolation between the values either side of the threefold stimulation index provides a robust assessment of the EC3 value without the need for recourse to more sophisticated statistical techniques. Expand
Food processing and allergenicity.
TLDR
The overall conclusion drawn is that processing does not completely abolish the allergenic potential of allergens, and there remains a need to develop robust and integrated methods for the risk assessment of food allergenicity. Expand
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