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Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a µ-agonist δ-antagonist and δ-inverse agonists
TLDR
Enantiomeric N-phenethyl-m-hydroxyphenylmorphans with various substituents in the ortho, meta or para positions of the aromatic ring in the phenethylamine side-chain, as well as a pyridylethyl and a indolylethyl moiety on the nitrogen atom, were synthesized and their binding affinity to the µ, δ, and κ-opioid receptors was examined.
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Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate
TLDR
From mice immunized with a globo H-KLH synthetic conjugate an IgG3 monoclonal antibody (mAb VK-9) was derived that recognizes the Globo H structure and could also recognize globe H-ceramide and human tumor cells expressing globoside.
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Defining the Molecular Recognition of MBr1 (Human Breast Cancer) Antigen by the MBr1 Antibody through Probe Structures Prepared by Total Synthesis
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Synthesis of π‐Extended Coumarins and Evaluation of Their Precursors as Reactive Fluorescent Probes for Mercury Ions
An efficient synthetic route to π-extended coumarin derivatives and their precursors that contain amino substituents has been developed. The synthesis involves monosubstitution of…
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A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle.
TLDR
Human trials on the globo H carbohydrate vaccine show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer.
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Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
  • Han Yu, I. Kim, K. Rice
  • Biology, Chemistry
    Journal of medicinal chemistry
  • 14 April 2004
TLDR
In their efforts toward developing a nonselective ligand that would block the effects of stimulants such as methamphetamine at dopamine, serotonin, and norepinephrine transporters, a series of 3-(3,4-dichlorophenyl)-1-indanamine derivatives were synthesized.
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Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen
The total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, is related. The construction involved the assembly of four glycals:  (17 (twice), 18, 20, and 26) and an…
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Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine
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Total synthesis of (′)-ceratopicanol
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A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.
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