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Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a µ-agonist δ-antagonist and δ-inverse agonists
Enantiomeric N-phenethyl-m-hydroxyphenylmorphans with various substituents in the ortho, meta or para positions of the aromatic ring in the phenethylamine side-chain, as well as a pyridylethyl and a indolylethyl moiety on the nitrogen atom, were synthesized and their binding affinity to the µ, δ, and κ-opioid receptors was examined.
Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate
From mice immunized with a globo H-KLH synthetic conjugate an IgG3 monoclonal antibody (mAb VK-9) was derived that recognizes the Globo H structure and could also recognize globe H-ceramide and human tumor cells expressing globoside.
Defining the Molecular Recognition of MBr1 (Human Breast Cancer) Antigen by the MBr1 Antibody through Probe Structures Prepared by Total Synthesis
Synthesis of π‐Extended Coumarins and Evaluation of Their Precursors as Reactive Fluorescent Probes for Mercury Ions
An efficient synthetic route to π-extended coumarin derivatives and their precursors that contain amino substituents has been developed. The synthesis involves monosubstitution of…
A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle.
Human trials on the globo H carbohydrate vaccine show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer.
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
In their efforts toward developing a nonselective ligand that would block the effects of stimulants such as methamphetamine at dopamine, serotonin, and norepinephrine transporters, a series of 3-(3,4-dichlorophenyl)-1-indanamine derivatives were synthesized.
Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen
The total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, is related. The construction involved the assembly of four glycals: (17 (twice), 18, 20, and 26) and an…
Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine
Total synthesis of (′)-ceratopicanol