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Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition
A crystallographic study reveals the structural basis for regulation by two different inhibitors of the actin capping protein, a critical factor controlling actin-driven cell motility.
Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex
The results demonstrate that Rg1‐induced antidepressant effects are might be mediated, in part, by protecting astrocyte gap junctions within the prefrontal cortex, indicating beneficial effects on the functional activity of gap junction channels in the brain. Expand
Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the
Findings suggest that above four compounds and nobiletin in the Nchinpi extract mainly cooperated to facilitate potently CRE-mediated transcription linked to the upstream cAMP/PKA/ERK/CREB pathway in hippocampal neurons. Expand
Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin–proteasome system in PC12D cells
The data suggest that p40-TH is prone to be insolubilized and aggregated by dysfunction of an ubiquitin–proteasome system in PC12D cells. Expand
Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.
Data demonstrated that DA deficiency should induce compensatory activation of TH via phosphorylation at (40)Ser through D2-autoreceptor and PKA-mediated pathways, which in turn give a rise to its degradation through an ubiquitin-proteasome pathway, resulting in a negative spiral of DA production when DA deficiency persists. Expand
Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons
Detailed morphological analysis revealed that FABP3 is critical for α-Synuclein uptake in dopaminergic neurons, thereby preventing synucleinopathies, including Parkinson′s disease. Expand
Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its
In cultured rat adrenal chromaffin cells, imidacloprid alone did facilitate tyrosine hydroxylase (TH) transcription via activation of α3β4 nAChR and the α7 subunit-comprising receptor, indicating its partial agonist-like action. Expand
SLC10A4 is a protease-activated transporter that transports bile acids.
It is demonstrated that SLC10A4 appears to be a protease-activated transporter and transports bile acids. Expand
Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain
Overall, FABP3 enhances α-Syn spreading in the brain following α- Syn PFF injection, and the FABp3 ligand MF1 represents an attractive therapeutic candidate for α-synucleinopathy. Expand
Extracellular α‐synuclein enters dopaminergic cells by modulating flotillin‐1–assisted dopamine transporter endocytosis
It is found that extracellular monomeric and fibrillar α‐SYN can potentiate FLOT1–dopamine transporter (DAT) binding and pre‐endocytic clustering of DAT on the cell surface, thereby facilitating DAT endocytosis and down‐regulating its transporter activity. Expand