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Metabolic gene polymorphism frequencies in control populations.
- S. Garte, L. Gaspari, E. Taioli
- BiologyCancer epidemiology, biomarkers & prevention : a…
- 1 December 2001
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes in the human population were determined.
Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.
Meta- and pooled analyses of published and unpublished, case-control, genotype-based studies that examined the association between GSTM1 null status and bladder cancer indicate that, among populations studied to date, GSTM 1 null status is associated with a modest increase in the risk of bladder cancer.
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
It is suggested that the CYP1A1 Ile(462)Val variant allele might play a role in lung carcinogenesis among non-smokers, possibly in combination with the GSTM1 null genotype.
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk.
A pooled analysis of the original data of about 9500 subjects involved in 21 case-control studies from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of GSTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power.
Molecular epidemiology studies of carcinogenic environmental pollutants. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage.
The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following exposure to environmental air…
Germ line polymorphisms of the tumor suppressor gene p53 and lung cancer.
Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.
A meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer found no significant interaction was observed between GST T1 and smoking on lung cancer, whereas GSTT 1 appeared to modulate occupational-related lung cancer.
Effects of environmental air pollution on endogenous oxidative DNA damage in humans.
Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.
- E. Taioli, L. Gaspari, S. Garte
- Medicine, BiologyInternational journal of epidemiology
- 1 February 2003
The results suggest that metabolic genetic factors play a role in lung cancer developing at young age, and are confined to never smokers.