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Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263–272,Expand
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Normal prion protein has an activity like that of superoxide dismutase.
We show here that mouse prion protein (PrP(C)) either as recombinant protein or immunoprecipitated from brain tissue has superoxide dismutase (SOD) activity. SOD activity was also associated withExpand
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The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines
Viral fusion proteins mediate the merger of host and viral membranes during cell entry for all enveloped viruses. Baculovirus glycoprotein gp64 (gp64) is unusual in promoting entry into both insectExpand
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Protein-disulfide Isomerase-mediated Reduction of Two Disulfide Bonds of HIV Envelope Glycoprotein 120 Occurs Post-CXCR4 Binding and Is Required for Fusion*
The human immunodeficiency virus (HIV) envelope (Env) glycoprotein (gp) 120 is a highly disulfide-bonded molecule that attaches HIV to the lymphocyte surface receptors CD4 and CXCR4. ConformationExpand
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Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen
Foot-and-mouth disease remains a major plague of livestock and outbreaks are often economically catastrophic. Current inactivated virus vaccines require expensive high containment facilities forExpand
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Crystal structure of SIV matrix antigen and implications for virus assembly
SIMIAN immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV)1, their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of PrSSGag, the soleExpand
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Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies
Treatment of emerging RNA viruses is hampered by the high mutation and replication rates that enable these viruses to operate as a quasispecies. Declining honey bee populations have been attributedExpand
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Consequences of manganese replacement of copper for prion protein function and proteinase resistance
The prion protein (PrP) binds copper and has antioxidant activity enhancing the survival of neurones in culture. The ability of the PrP to bind other cations was tested and it was found that onlyExpand
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The molecular basis of HIV capsid assembly—five years of progress
The assembly of HIV is relatively poorly investigated when compared with the process of virus entry. Yet a detailed understanding of the mechanism of assembly is fundamental to our knowledge of theExpand
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Eukaryotic Virus Display: Engineering the Major Surface Glycoprotein of the Autographa californica Nuclear Polyhedrosis Virus (AcNPV) for the Presentation of Foreign Proteins on the Virus Surface
We describe the development of the baculovirus Autographa californica nuclear polyhedrosis virus (AcNPV) as a vector for the display of distinct proteins on the viral surface in a manner that isExpand
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