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Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development1, 2. The NMDA receptor channel is formed by at… Expand
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.
It is shown that targeted disruption of the mouse epsilon 1 subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses, which supports the notion that the NMda receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning. Expand
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.
Results indicate that DHPG is a specific and potent agonist of mGluRs and has no effect on ionotropic glutamate receptors whose expression was induced in the oocytes following injection of poly(A)+ mRNA of rat brains. Expand
A new type of glutamate receptor linked to inositol phospholipid metabolism
Evidence is reported for a new type of Glu receptor, which prefers Q A as agonist, and which directly activates inositol phospholipid metabolism through interaction with GTP-binding regulatory proteins, leading to the formation of inositl 1,4,5-trisphosphate (InsP3) and mobilization of intracellular Ca2+. Expand
Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry
It is reported that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRϵ2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. Expand
Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry.
It is reported that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRepsilon2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. Expand
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices and the amplitudes of the potentiation were not changed by the formation of long‐term potentiation. Expand
Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus
The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP. Expand
Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses.
Investigation of the roles of glutamate (Glu) receptors in the mechanism of long-term potentiation observed in rat hippocampal mossy fiber synapses found tetanic stimulation produced robust LTP even when the synaptic transmission was blocked postsynaptically by iGluR antagonists. Expand
Horseshoe Crab Hemocyte-derived Antimicrobial Polypeptides, Tachystatins, with Sequence Similarity to Spider Neurotoxins*
- T. Osaki, M. Omotezako, +7 authors S. Kawabata
- Biology, Medicine
- The Journal of Biological Chemistry
- 10 September 1999
As horseshoe crab is a close relative of the spider, tachystatins and spider neurotoxins may have evolved from a common ancestral peptide, with adaptive functions. Expand